PTP4A3 vervult een essentiële functie binnen de tumorvorming en metastase van een aantal tumoren , maar de prognostische functie ervan bij de meeste nierkankers zal niet effectief worden begrepen. We gebruik gemaakt van de Oncomine en Tumor Immunoassay Nuttig resource databases te kijken naar de differentiële expressie van PTP4A3 in tumor weefsels en regelmatige weefsels in de borst, urinewegen, maagdarmkanaal en poriën en de huid.
Gebruik makend van de GEPIA en PrognoScan databases, de onpartijdige prognostische functie van PTP4A3 werd bevestigd in clear cell niercelcarcinoom meeste vormen van kanker en papillaire niercelkanker meeste vormen van kanker . Expressie van PTP4A3 was duidelijk groter in tumorweefsel , te evalueren met reguliere weefsels ( P = 0,028).
We hebben de associaties van PTP4A3 en klinisch-pathologische opties niet ontdekt in ons IHC- cohort. Ectopische expressie van PTP4A3 bevordert proliferatie, migratie en invasie en verhoogde het mRNA-stadium van TGFB1 in RCC-celstammen.
Immunohistochemische kleuring gaf aan dat de expressie van PTP4A3 associeert met CD3 + ( P = 0,037) / CD8 + ( P = 0,037) intra tumor TIL, niet met invasieve marges renale kanker . Volledige evaluatie van immuuninfiltratie in de TIMER-database correleerde PTP4A3-expressie met de infiltratie van B-cellen, CD8+ T-cellen, CD4+ T- cellen en neutrofielen in elk heldercellig niercelcarcinoom en papillair niercelcarcinoom.
PTP4A3-expressie was gerelateerd aan de infiltratie van dendritische cellen in papillair niercelcarcinoom. We bevestigden bovendien dat de infiltratie van B-cellen en CD8+ T-cellen gerelateerd was aan een slechte prognose bij patiënten met papillair niercelcarcinoom, in overeenstemming met de prognostische functie van PTP4A3 bij papillair niercelcarcinoom.
PTP4A3-expressie correleerde genen in B-cellen, monocyten, M1-macrofagen, Th2- en Treg-cellen in papillair niercelcarcinoom. Deze uitkomsten raden PTP4A3 aan als een prognostische kwestie met een baan bij het reguleren van de infiltratie van immuuncellen bij papillair niercelcarcinoom.
hnRNPA2B1 bevordert de dikke darm De meeste kankers Ontwikkeling via de MAPK-route
HNRNPA2B1, een RNA bindend eiwit, vervult een belangrijke functie in grote microRNA verwerking, verschillende splicing, mRNA metabolisme en transport. Merkwaardig , hnRNPA2B1 bovendien werkt als N6-methyladenosine (M6A) lezer en is essentieel gedurende tumorgenese van diverse weefsels variëteiten .
Niettemin , zijn functie in de dikke darm kanker blijft onduidelijk. Bij dit onderzoek wilden we de organische mogelijkheden van hnRNPA2B1 ophelderen en de onderliggende mechanismen ervan ontdekken bij de meeste kankers in de dikke darm . We onderzochten de expressie van hnRNPA2B1 in Oncomine- en TCGA-databases.
Verifieerde vervolgens de bevindingen in de meeste kankercellen van de dikke darm en medische monsters met western blotting en immunohistochemie ( IHC ). We gebruikten CRISPR / Cas9 gerichte gen verhogen knockout hnRNPA2B1 expressie in humane colon kanker cellijn SW480 en HCT-116 en uitgevoerd elke in vivo en in vitro experimenten. De resultaten zijn bovendien bevestigd door RNA-seq-analyses.
We ontdekten dat hnRNPA2B1 aanzienlijk bevorderd dikke darm kanker celproliferatie elk in vitro en in vivo , terwijl knock-out van hnRNPA2B1 geïnduceerde apoptose en celcyclus arrestatie in SW480. RNA-seq-analyses onthulden dat de ERK / MAPK-route werd geactiveerd door hnRNPA2B1-upregulatie.
Naast , elke hnRNPA2B1 en MAPK route is geactiveerd medische colon kanker specimens en positief gecorreleerd. Mechanistisch gezien leek hnRNPA2B1 een stroomopwaartse regulator van de ERK/MAPK-route te zijn en remming van MAPK-signalering blokkeerde de gevolgen van hnRNPA2B1.
Taken collectief , onze gegevens blijkt dat de RNA-bindende eiwit hnRNPA2B1 stimuleert celproliferatie en reguleert celcyclus en apoptose van menselijke colon kanker door activering van de ERK / MAPK -signalering, die presenteren een nieuwe waarneming in geval van hnRNPA2B1 als een mogelijke therapeutisch doel voor de remedie van de meeste kankers van de dikke darm .
Metaplastisch borstcarcinoom: klinisch-pathologische parameters en prognostisch profiel
Inleiding Metaplastisch borstcarcinoom (MBC) wordt geschetst als de meeste borstkankers met een heteroloog niet-glandulair element . MBC houdt rekening met een bepaald soort borstkanker, de meeste kankers met een prognose die slechter is dan invasief ductaal carcinoom (IDC) van de borst. MBC is de meest typische borsten meeste vormen van kanker met een triple-negatieve profiel.
Vanwege dit feit , op deze onderzoeken , evalueerden we tot de klinische parameters, herhaling en overleving van MBC in onze inwoners . Strategieën We voerden een retrospectief observationeel onderzoek uit binnen de afdeling Histopathologie van het Prince Faisal Oncology Centre, Buraidah, Saoedi-Arabië, over een interval van 5 jaar.
Alle omstandigheden geïdentificeerd als MBC zijn opgenomen in het te onderzoeken . Oestrogeenreceptor (ER), progesteronreceptor (PR) en epidermale humane ontwikkeling probleem receptor 2 (HER2 / neu) immunohistochemie ( IHC ) werd uitgevoerd op consultant weefsel blokken. Uitkomsten Whole 183 omstandigheden van MBC’s zijn opgenomen in het onderzoek , waarvan 120 omstandigheden zijn excisie specimens.
De impliciete leeftijd van de patiënten was 48,84 ± 12,99 jaar, en de meest typische leeftijdsgroep was tussen 36 en 50 jaar. Veel van de omstandigheden waren tumor (T) stadium T3 (50%), en nodale metastase was actueel in 40% van de omstandigheden .
De meeste omstandigheden waren graad III (78,7%). ER-, PR- en HER2/neu-positiviteit was beroemd in respectievelijk 15,8%, 13,1% en 9,8%. Observatie-informatie is al 70 omstandigheden beschikbaar, met een mediane follow-up-interval van 4 (1-7) jaar. Tumorrecidief was beroemd in 31,4% omstandigheden, met een overlevingspercentage van 71,4%. Plaveiselcel, chondroïde, spilceldifferentiatie en matrixproductie zijn beroemd in respectievelijk 70,5%, 7,1%, 13,7% en een paar,2% omstandigheden.
Een belangrijke verwantschap van squameuze differentiatie was beroemd met HER2 / neu-positiviteit. Een omgekeerde verwantschap van spilceldifferentiatie werd gezien bij okselmetastasen. Survival evaluatie door Kaplan-Meier onthulde een grote aansluiting van de overleving met tumor recidief.
Conclusie MBC is een essentieel subtype van de meeste borstkankers , waarvan histopathologische identificatie moeilijk is vanwege verschillende histologische differentiatie. We ontdekten dat squameuze differentiatie de meest typische is in MBC, wat gerelateerd was aan HER2 / neu-positiviteit. Een buitensporig recidief van MBC werd bovendien opgemerkt in ons onderzoek dat aanzienlijk verband hield met overleving.
SOX9 is gerelateerd aan superieure T-stadia van medisch stadium II colon, de meeste kankers bij jongere Mexicaanse patiënten
De meeste colorectale kankers (CRC) is zonder twijfel een van de meest voorkomende maligniteiten ter wereld en bevat de meeste kankers van de dikke darm (CC) en de meeste rectale kankers (RC). Betreffende CC geval van nieuwe moleculaire biomarkers voor correcte analyse en prognose, naast de identificatie van nieuwe doelwitten voor therapeutische interventie, dringend gezocht .
SRY-verwante groep hoge mobiliteit veld 9 (SOX9), een transcriptie probleem wordt betrokken bij groei , en is gerelateerd aan de ontwikkeling van humane kanker . Niettemin , de onderliggende medische en bruikbare resultaten in CRC niet zijn helemaal begrepen. Vanwege dit feit was het huidige onderzoek gericht op het beoordelen van de medische en bruikbare relevantie van SOX9-expressie in CC.
De expressie van SOX9 in tumor weefsel werd geëvalueerd in 97 biopten van Mexicaanse patiënten met CC met een vroeg stadium I en II ziekte door middel van immunohistochemie ( IHC ). Evenals werd SOX9-silencing binnen de HCT116-cellijn uitgevoerd met behulp van bepaalde kleine interfererende RNA’s, terwijl de effectiviteit van de neerwaartse regulatie werd geverifieerd door reverse transcriptie-kwantitatieve PCR en immunofluorescentie.
Sferoïde-vormingstest werd uitgevoerd met behulp van ultra-lage bevestigingsplaten. De IHC- resultaten bevestigden dat SOX9 was opgereguleerd bij patiënten met stadium II (91%) en superieure T3-stadium (67%) CC. Merkwaardig , groter is SOX9 expressie betrekking op medische stadium tumor meet- en tumor locatie. Bovendien was verhoogde SOX9-expressie aanwezig in recidiverende omstandigheden met inheemse tumoren ; niettemin , Het was niet gerelateerd aan een verhoogde overleving waarschijnlijkheid .
Multiple organ tumor tissue array |
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| MC485a | TissueArray | each | EUR 222 |
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Description: Multiple organ tumor tissue array, including pathology grade, TNM and clinical stage (lung small cell carcinoma reference AJCC 8th version, others reference AJCC 7th version), 24 cores/48 cores, replacing MC485 |
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Multiple organ tumor tissue array |
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| MC964b | TissueArray | each | EUR 306 |
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Description: Multiple organ tumor tissue array, including TNM, clinical stage and pathology grade, 96 cases/96 cores, replacing MC964a |
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Multiple organ tumor tissue array |
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| TP481a | TissueArray | each | EUR 198 |
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Description: Multiple organ tumor tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 48 cores/48 cores, replacing TP481 |
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Multiple organ tumor tissue array |
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| MC2081a | TissueArray | each | EUR 546 |
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Description: Multiple organ tumor tissue array, including TNM, clinical stage and pathology grade, 208 cases/208 cores, replacing MC2081 |
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Multiple organ tumor tissue array |
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| MC2082D | TissueArray | each | EUR 545 |
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Description: Multiple organ tumor tissue array, including pathology grade, TNM and clinical stage, 192 cases/192 cores, replacing MC2082c |
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Multiple Kidney cancer tissue array with normal tissue control from autopsy |
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| KD483 | TissueArray | each | EUR 168 |
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Description: Multiple Kidney cancer tissue array with normal tissue control from autopsy, 48 cases/48 cores, with stage and grade data |
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Multiple Kidney cancer test tissue array with unmatched normal adjacent tissue |
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| KD242 | TissueArray | each | EUR 48 |
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Description: Multiple Kidney cancer test tissue array with unmatched normal adjacent tissue, 10 cases/24 cores |
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Tissue, Array, Human Tumor (Adult), Multiple Tumor, Bladder, Breast, Colon, Esophagus, Kidney, Liver, Lung, Ovary, Prostate, Skin, Stomach, Uterus (Paraffin) |
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| MBS639641-5Slides | MyBiosource | 5Slides | EUR 1280 |
Tissue, Array, Human Tumor (Adult), Multiple Tumor, Bladder, Breast, Colon, Esophagus, Kidney, Liver, Lung, Ovary, Prostate, Skin, Stomach, Uterus (Paraffin) |
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| MBS639641-5x5Slides | MyBiosource | 5x5Slides | EUR 5620 |
Multiple normal organ tissue with tumor tissue array |
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| BCN911 | TissueArray | each | EUR 306 |
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Description: Multiple normal organ tissue with tumor tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 91 cases/91 cores |
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Multiple organ tumor with normal tissue array |
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| NE921 | TissueArray | each | EUR 295 |
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Description: Multiple organ tumor with normal tissue array, 20 cases neuroendocrine tumor) including pathology grade, TNM and clinical stage (small cell carcinoma reference AJCC 8th edition), 46 cases/92 cores (core size 1.5mm) |
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Multiple organs tumor and normal tissue array |
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| MC1501A | TissueArray | each | EUR 474 |
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Description: Multiple organs tumor and normal tissue array, including TNM, clinical stage and pathology grade, 150 cases/150 cores, replacing BC001134b |
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Multiple organs tumor and normal tissue array |
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| MC2501 | TissueArray | each | EUR 678 |
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Description: Multiple organs tumor and normal tissue array, with TNM, clinical stage and pathology grade, 250 cases/250 cores |
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Multiple organ tumor with normal tissue array |
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| MC482 | TissueArray | each | EUR 198 |
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Description: Multiple organ tumor with normal tissue array, including pathology grade, TNM and clinical stage, 40 cases/48 cores |
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Multiple organ tumor with normal tissue array |
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| T0014b | TissueArray | each | EUR 48 |
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Description: Multiple organ tumor with normal tissue array, including pathology grade, TNM and clinical stage, 6 cases/ 24 cores (1.5mm), replacing T0014a |
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Multiple testis tumor and testis tissue array |
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| TE482a | TissueArray | each | EUR 168 |
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Description: Multiple testis tumor and testis tissue array, including TNM and clinical stage, 24 cases/48 cores, replacing TE482 |
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Multiple organ tumor tissue array with adjacent normal tissue |
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| MC803b | TissueArray | each | EUR 336 |
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Description: Multiple organ tumor tissue array with adjacent normal tissue, including TNM and clinical stage, 40 cases/80 cores, replacing MC803a |
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Multiple stomach tumor with stomach tissue array |
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| ST821 | TissueArray | each | EUR 306 |
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Description: Multiple stomach tumor with stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 8th version), 80 cases/80 cores |
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Multiple tumor tissue array covers 53 types of benign |
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| BCN1021 | TissueArray | each | EUR 266 |
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Description: Multiple tumor tissue array covers 53 types of benign, malignant, regional lymph node and distant metastasis tumors with normal tissues as controls, including pathology grade, TNM/Stage (AJCC 8th edition), 102 cases/102 cores (core size 1.5mm) |
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Multiple tumor of pancreas and pancreas tissue array |
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| T142c | TissueArray | each | EUR 66 |
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Description: Multiple tumor of pancreas and pancreas tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replacing T142b |
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Kidney tumor tissue array with matched tumor adjacent kidney tissue |
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| KD2602a | TissueArray | each | EUR 354 |
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Description: Kidney tumor tissue array with matched tumor adjacent kidney tissue, including TNM, clinical stage and pathology grade, 65 cases/260 cores, replacing KD2602 |
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Tissue, Array, Human Tumor (Adult), Multiple Tumor, Bladder, Breast, Colon (Rectal), Kidney, Liver, Lung, Lymph Node, Ovary, Pancreas, Prostate, Skin, Stomach, Uterus (Paraffin) |
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| MBS639524-5Slides | MyBiosource | 5Slides | EUR 1280 |
Tissue, Array, Human Tumor (Adult), Multiple Tumor, Bladder, Breast, Colon (Rectal), Kidney, Liver, Lung, Lymph Node, Ovary, Pancreas, Prostate, Skin, Stomach, Uterus (Paraffin) |
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| MBS639524-5x5Slides | MyBiosource | 5x5Slides | EUR 5620 |
Multiple organs neuroendocrine tumor tissue array with normal tissue |
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| NE841 | TissueArray | each | EUR 354 |
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Description: Multiple organs neuroendocrine tumor tissue array with normal tissue |
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Immune multiple organs tumor and normal tissue array |
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| MC1081 | TissueArray | each | EUR 414 |
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Description: Immune multiple organs tumor and normal tissue array, containing 20 cases leukemia, 20 cases non-Hodgkin's lymphoma, 20 cases Hodgkin's lymphoma, 11 cases plasma cell myeloma, 9 cases extramedullary plasmacytoma, 20 cases malignant thymoma, plus 2 each cases of normal lymph node, spleen, bone marrow and thymus gland tissue, 108 cases/108 cores, |
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Multiple organ tumor and adjacent normal tissue array |
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| BCN963b | TissueArray | each | EUR 258 |
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Description: Multiple organ tumor and adjacent normal tissue array, including pathology grade, TNM and clinical stage, 81 cases/96 cores, replacing BCN963a |
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Multiple organ tumor with adjacent normal tissue array |
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| CM241a | TissueArray | each | EUR 66 |
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Description: Multiple organ tumor with adjacent normal tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 12 cases/24 cores, replacing CM241 |
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Multiple organ tumor with adjacent normal tissue array |
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| BCN721b | TissueArray | each | EUR 270 |
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Description: Multiple organ tumor with adjacent normal tissue array, including pathology grade, TNM and clinical stage, replaing BCN721a |
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Multiple organ tumor with adjacent normal tissue array |
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| MC486 | TissueArray | each | EUR 270 |
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Description: Multiple organ tumor with adjacent normal tissue array, including pathology grade, TNM and clinical stage, 48 cases/48 cores, replacing BC00116 |
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Multiple head and neck tumor with normal tissue array |
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| HN802d | TissueArray | each | EUR 306 |
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Description: Multiple head and neck tumor with normal tissue array, including squamous cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, pathology grade, TNM and clinical stage (AJCC 8th edition), 80 cases/80 cores (core size 1.5mm), replacing HN802c |
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Multiple types skin tumor with matched tumor adjacent tissue array |
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| SK801d | TissueArray | each | EUR 258 |
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Description: Multiple types skin tumor with matched tumor adjacent tissue array, including pathology grade, TNM and clinical stage, 70 cases/80 cores (cores size 1.5mm), replacing SK801c |
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Multiple tumor (24 organs )and normal (6 organs) tissue array |
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| FDA808l-2 | TissueArray | each | EUR 306 |
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Description: Multiple tumor (24 organs )and normal (6 organs) tissue array, with grade and TNM/Stage,72 cases/72 cores (core size 1.5mm), replacing FDA808k-2 |
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Recent Years Collection Samples. Multiple ovarian tumor tissue array |
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| OV401sur | TissueArray | each | EUR 416 |
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Description: Recent Years Collection Samples. Multiple ovarian tumor tissue array, including survival data, pathology grade, TNM and clinical stage (AJCC 8.0), 20 cases/40 cores (1.5mm) |
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Multiple organ tumor with matched adjacent normal tissue array |
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| MC246b | TissueArray | each | EUR 66 |
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Description: Multiple organ tumor with matched adjacent normal tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replaced by MC246c |
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Multiple sites of head and neck tumor ad normal tissue array |
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| HN721 | TissueArray | each | EUR 306 |
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Description: Multiple sites of head and neck tumor ad normal tissue array, including pathology grade, TNM and clinical stage, 72 cases/72 cores |
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Multiple organ tumor with neuroendocrine differentiation tissue array |
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| BC01072 | TissueArray | each | EUR 270 |
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Description: Multiple organ tumor with neuroendocrine differentiation tissue array, including pathology grade, TNM and clinical stage, 36 cases/72 cores |
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Kidney tumor tissue array with normal tissue as control |
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| KD961 | TissueArray | each | EUR 258 |
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Description: Kidney tumor tissue array with normal tissue as control, including TNM, clinical stage and pathology grade, 48 cases/96 cores |
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Multiple ovarian tumor with matched cancer adjacent ovary tissue array |
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| OV901 | TissueArray | each | EUR 306 |
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Description: Multiple ovarian tumor with matched cancer adjacent ovary tissue array, including serous carcinoma, clear cell carcinoma, endometrioid adenocarcinoma,mucinous adenocarcinoma,disgerminoma,yolk sac tumor and sertoli-Leydig cell tumors and mixed germ cell tumor,thology grade, TNM and clinical stage (AJCC 8.0), 76 cases/90 cores (1.5mm) |
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Multiple organs tumor with normal tissue array and cell line samples |
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| MC1251 | TissueArray | each | EUR 414 |
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Description: Multiple organs tumor with normal tissue array and cell line samples, including pathology grade, TNM and stage, 132 cases/132 cores |
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Multiple cancer tissue array |
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| MC801 | TissueArray | each | EUR 306 |
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Description: Multiple cancer tissue array, replacing BC00012, 80 cases/80 cores, with grade information |
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Multiple lymphoma tissue array |
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| LM241b | TissueArray | each | EUR 66 |
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Description: Multiple lymphoma tissue array, 12 cases/24 cores (core size 1.0mm), replacing LM241 |
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Multiple Tumor Tissue Array - 12 major types of cancer paired with adjacent normal tissues |
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| Z7020080 | Biochain | 5 slides | EUR 1125.6 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Multiple Species Tissue Slides - Kidney Tissue |
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| 10-400-MSTA | ProSci | 1 pack | EUR 241.8 |
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Description: The Multiple Species Tissue Array (MSTA) slides were designed to study protein expression patterns in different cells and tissues from multiple species. Tissue slices from three different species are mounted on each MSTA slide which can then be treated as a single histological slide for H&E staining, immunohistochemistry, or in situ hybridization. This format allows a rapid analysis of protein expression and localization across different species. MSTA slides can also be used to quickly determine the species reactivity of a given antibody. |
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Multiple Species Tissue Slides - Kidney Tissue |
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| MBS154195-1Pack | MyBiosource | 1Pack | EUR 210 |
Multiple Species Tissue Slides - Kidney Tissue |
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| MBS154195-5x1Pack | MyBiosource | 5x1Pack | EUR 920 |
Multiple organs tumor with normal tissue array and with cell line samples |
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| MC1250 | TissueArray | each | EUR 414 |
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Description: Multiple organs tumor with normal tissue array and with cell line samples, including pathology grade, TNM and stage, 132 cases/132 cores |
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Multiple organ (23 types) tumor and unmatched normal adjacent (NAT) tissue array |
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| MC461 | TissueArray | each | EUR 192 |
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Description: Multiple organ (23 types) tumor and unmatched normal adjacent (NAT) tissue array, including pathology grade, TNM and clinical stage, 46 cases/46 cores, replacing BC00432 |
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Tissue, Array, Human Disease (Adult), Kidney Tumor (Paraffin) |
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| MBS639684-5Slides | MyBiosource | 5Slides | EUR 1280 |
Tissue, Array, Human Disease (Adult), Kidney Tumor (Paraffin) |
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| MBS639684-5x5Slides | MyBiosource | 5x5Slides | EUR 5620 |
Tissue, Array, Human Tumor (Adult), Multiple Tumor, Brain, Breast, Colon, Liver, Lung, Prostate, Tonsil (Paraffin) |
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| MBS639460-5Slides | MyBiosource | 5Slides | EUR 515 |
Tissue, Array, Human Tumor (Adult), Multiple Tumor, Brain, Breast, Colon, Liver, Lung, Prostate, Tonsil (Paraffin) |
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| MBS639460-5x5Slides | MyBiosource | 5x5Slides | EUR 2175 |
Multiple lung cancer tissue array |
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| LC20813c | TissueArray | each | EUR 546 |
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Description: Multiple lung cancer tissue array, including pathology grade, TNM and clinical stage, 192 cases/192 cores, replacing LC120813b |
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Multiple lung cancer tissue array |
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| LC20815a | TissueArray | each | EUR 546 |
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Description: Multiple lung cancer tissue array, including pathology grade, TNM and clinical stage (small cell carcinoma is referenced AJCC 8th version), 208 cases/208 cores, replacing LC20815 |
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Multiple types brain tumor tissue array, including pathology grade, 96 cases/96 cores |
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| NCT961 | BioCoreUSA | row: 8; column: 12; cores: 96; cases: 96 | EUR 378 |
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Description: Multiple types brain tumor tissue microarray, containing 56 cases of brain glioma (pathology grade:I-IV), 6 ependymoma, 22 meningioma, plus 12 cerebrum tissue, single cores per case |
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Multiple organ normal tissue array |
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| BN00011b | TissueArray | each | EUR 168 |
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Description: Multiple organ normal tissue array, 44 cases/48 cores, replacing BN00011a |
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Multiple normal organ tissue array |
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| BN114c | TissueArray | each | EUR 168 |
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Description: Multiple normal organ tissue array, 40 cases/48 cores, replacing BN114b |
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Multiple organ normal tissue array |
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| BN117a | TissueArray | each | EUR 168 |
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Description: Multiple organ normal tissue array, 45 cases/45 cores, replaced by BN117b |
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Multiple organ normal tissue array |
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| BN117b | TissueArray | each | EUR 168 |
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Description: Multiple organ normal tissue array, 37 cases/45 cores, replacing BN117a |
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Multiple organ normal tissue array |
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| BN119a | TissueArray | each | EUR 66 |
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Description: Multiple organ normal tissue array, 17 cases/19 cores, replacing BN119 |
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Multiple organ normal tissue array |
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| BN126 | TissueArray | each | EUR 270 |
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Description: Multiple organ normal tissue array, replacing BN113, 45 cases/45 cores |
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Multiple organ normal tissue array |
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| BN129a | TissueArray | each | EUR 168 |
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Description: Multiple organ normal tissue array, 34 cases/48 cores, replacing BN129 |
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Multiple organ normal tissue array |
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| BN151 | TissueArray | each | EUR 78 |
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Description: Multiple organ normal tissue array, 15 case/15 cores, replacing MNC151 |
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Multiple organ normal tissue array |
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| BN242d | TissueArray | each | EUR 66 |
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Description: Multiple organ normal tissue array, 11 cases/24 cores, replacing BN242c |
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Multiple organ normal tissue array |
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| BN243d | TissueArray | each | EUR 78 |
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Description: Multiple organ normal tissue array, 12 cases/24 cores, replacing BN243c |
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Multiple organ normal tissue array |
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| BN483b | TissueArray | each | EUR 168 |
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Description: Multiple organ normal tissue array, 24 cases/ 48 cores, replacing BN483a |
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Multiple organ normal tissue array |
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| BN484 | TissueArray | each | EUR 234 |
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Description: Multiple organ normal tissue array, 24 cases/48 cores |
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Multiple organ normal tissue array |
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| BN501a | TissueArray | each | EUR 168 |
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Description: Multiple organ normal tissue array, 50 cases/50 cores, replacing BN501 |
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Multiple organ normal tissue array |
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| BN961b | TissueArray | each | EUR 306 |
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Description: Multiple organ normal tissue array, 24 cases/96 cores, replacing BN961a |
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Multiple organ cancer tissue array |
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| BC000111b | TissueArray | each | EUR 168 |
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Description: Multiple organ cancer tissue array, including TNM, clinical stage and pathology grade, 39 cases/39 cores, replacing BC000111a |
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Multiple organ cancer tissue array |
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| BC000119b | TissueArray | each | EUR 546 |
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Description: Multiple organ cancer tissue array, including pathology grade, TNM, clinical stage, Gleason grade and Gleason score, 190 cases/190 cores, replacing BC000119a |
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Multiple organ cancer tissue array |
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| BC000120b | TissueArray | each | EUR 546 |
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Description: Multiple organ cancer tissue array, including pathology grade, TNM and clinical stage, 190 cases/190 cores, replacing BC000120a |
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Multiple organ normal tissue array |
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| MBN111 | TissueArray | each | EUR 78 |
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Description: Multiple organ normal tissue array, 11 cases/11 cores |
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Multiple organ cancer tissue array |
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| MC543 | TissueArray | each | EUR 354 |
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Description: Multiple organ cancer tissue array, including TNM and pathology grade, 54 cases/ 54 cores |
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Kidney Tumor Tissue Array - 12 cases of kidney cancer paired with adjacent normal tissues |
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| Z7020053 | Biochain | 5 slides | EUR 1125.6 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Multiple Tumor Tissue Array - Duplicated 48 cases of benign and malignant tumors of the nervous system |
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| Z7020084 | Biochain | 5 slides | EUR 1657.2 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Multiple Tumor Tissue Array - 24 duplicated cases of gastrointestinal stroma tumor with various grades and stages. |
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| Z7020038 | Biochain | 5 slides | EUR 1657.2 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Multiple cancer (3 types) tissue array |
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| MC243b | TissueArray | each | EUR 108 |
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Description: Multiple cancer (3 types) tissue array, including TNM, clinical stage and pathology grade, 24 cases/ 24 cores, replacing MC243a |
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Multiple organ leiomyosarcoma tissue array |
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| SO8013 | TissueArray | each | EUR 258 |
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Description: Multiple organ leiomyosarcoma tissue array, including TNM and pathology grade, 80 cases/ 80 cores |
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Kidney tissue array |
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| KD803b | TissueArray | each | EUR 354 |
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Description: Kidney tissue array, 80 cases/80n cores (core size 1.5mm), replacing KD803a |
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Multiple organ lymph node tissue array |
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| LN802a | TissueArray | each | EUR 270 |
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Description: Multiple organ lymph node tissue array, 80 cases/80 cores, replacing LN802 |
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Multiple diseases of liver tissue array |
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| LV1201b | TissueArray | each | EUR 474 |
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Description: Multiple diseases of liver tissue array, includin pathology grade, TNM and clinical stage, 118 cases/120 cores, replacing LV1201a |
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Multiple organ cancer test tissue array |
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| T009 | TissueArray | each | EUR 48 |
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Description: Multiple organ cancer test tissue array, with normal tissue, including TNM and pathology grade, 6 cases/24 cores |
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Mouse multiple organ normal tissue array |
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| MO1601b | TissueArray | each | EUR 270 |
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Description: Mouse multiple organ normal tissue array, 160 cases/160 cores, replacing MO1601a |
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Mouse multiple organ normal tissue array |
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| MO541e | TissueArray | each | EUR 138 |
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Description: Mouse multiple organ normal tissue array, 10 cases/54 cores, replacing MO541d |
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Multiple organ normal tissue of fetus tissue array |
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| BE01014a | TissueArray | each | EUR 222 |
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Description: Multiple organ normal tissue of fetus tissue array, 26 organs/78 cores, replacing BE01014 |
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Multiple types breast cancer tissue array |
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| BR1003a | TissueArray | each | EUR 306 |
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Description: Multiple types breast cancer tissue array, including pathology grade, TNM and clinical stage, 47 cases/101 cores, replacing BR1003 |
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Multiple stomach tumor with matched cancer adjacent or adjacent normal stomach tissue array |
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| ST820 | TissueArray | each | EUR 306 |
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Description: Multiple stomach tumor with matched cancer adjacent or adjacent normal stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 40 cases/80 cores |
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Normal gastric tissue array (multiple parts) |
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| BN01013b | TissueArray | each | EUR 198 |
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Description: Normal gastric tissue array (multiple parts), 72 cases/72 cores, replacing BN01013a |
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Multiple organ normal tissue and cancer tissue array |
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| MC811 | TissueArray | each | EUR 306 |
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Description: Multiple organ normal tissue and cancer tissue array, including pathology grade, TNM and clinical stage, 75 cases/81 cores, replaced by BCN821 |
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Multiple organ normal tissue and cancer tissue array |
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| MC911 | TissueArray | each | EUR 354 |
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Description: Multiple organ normal tissue and cancer tissue array, including pathology grade, TNM and clinical stage, 83 cases/88 cores (core size 1.5mm) |
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Multiple rectal cancer tissue array with normal tissue |
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| RE482 | TissueArray | each | EUR 138 |
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Description: Multiple rectal cancer tissue array with normal tissue, stage and grade data, 48 cases/48 cores |
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Multiple Tumor Tissue Array - 12 types of human tissues in duplicates, designed as universal control for >90% routine IH |
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| Z7020083 | Biochain | 5 slides | EUR 321.6 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Multiple organ metastatic cancer tissue array |
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| MT2081 | TissueArray | each | EUR 474 |
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Description: Multiple organ metastatic cancer tissue array, 19 organ/104 cases/208 cores |
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Multiple organ cancer metastasis tissue array |
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| MT801 | TissueArray | each | EUR 306 |
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Description: Multiple organ cancer metastasis tissue array, 80 cases/80 cores (core size 1.5mm) |
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Kidney Tumor Tissue Array - 48 cases of uninvolved and cancerous tissues of the kidney in duplicates |
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| Z7020055 | Biochain | 5 slides | EUR 1657.2 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Kidney tumour with normal tissue array |
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| KD2001 | TissueArray | each | EUR 474 |
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Description: Kidney tumour with normal tissue array, including Clear cell carcinoma (CCRCC), Sarcomatoid carcinoma, Papillary renal cell carcinoma (PRCC), Chromopobe carcinoma(crcc), Invasive low grade urothelial carcinoma, with Isup Grade, TNM/Stage (AJCC 8th edition), 100 cases/200 cores (core size 1.0mm),replacing BC07114 |
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Multiple organs normal tissue array of rat |
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| RA161 | TissueArray | each | EUR 48 |
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Description: Multiple organs normal tissue array of rat, 8 cases/16 cores |
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Multiple organs normal tissue array of rat |
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| RA162 | TissueArray | each | EUR 48 |
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Description: Multiple organs normal tissue array of rat, 8 cases/16 cores |
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Multiple lymphoma tissue array (2008 WHO classification) |
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| LY2086b | TissueArray | each | EUR 474 |
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Description: Multiple lymphoma tissue array (2008 WHO classification), 192 cases/192 cores, replacing LY2086a |
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Multiple sites of normal brain tissue array |
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| BNC17011c | TissueArray | each | EUR 306 |
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Description: Multiple sites of normal brain tissue array, 26 case/80 cores, replacing BNC17011b |
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Multiple organ (24 types) normal tissue array |
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| MBN481b | TissueArray | each | EUR 234 |
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Description: Multiple organ (24 types) normal tissue array, 48 cases/48 cores, replacing MBN481a (1.5mm) |
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Multiple lung cancer with lung tissue array |
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| LC813b | TissueArray | each | EUR 270 |
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Description: Multiple lung cancer with lung tissue array, including pathology grade, TNM and clinical stage (small cell carcinoma and atypical carcinoid are referencing AJCC 8th version), 79 cases/80 cores, replacing LC813a |
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Multiple organ metastatic carcinoma tissue array |
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| MET961b | TissueArray | each | EUR 300 |
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Description: Multiple organ metastatic carcinoma tissue array, including pathology grade, 48 cases/96 cores, replacing MET961a |
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Multiple Tumor Tissue Array - 15 major types tumors. Most types have duplicates from different patients with correspondi |
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| Z7020081 | Biochain | 5 slides | EUR 1125.6 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Multiple Tumor Tissue Array - 40 types of tumors. Most of them have duplicates or triplicates from different individual |
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| Z7020082 | Biochain | 5 slides | EUR 1657.2 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Normal male dog multiple organs tissue array |
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| DGM281 | TissueArray | each | EUR 306 |
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Description: Normal male dog multiple organs tissue array, 25 organs/ 25cores |
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Multiple organs (24 types) normal tissue array |
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| FDA808l-1 | TissueArray | each | EUR 306 |
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Description: Multiple organs (24 types) normal tissue array, 24 organs/72 cores (core size 1.5mm), replacing FDA808k-1 |
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Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue III (5), kidney, control, lung, control, normal placenta (matched with mRNA blots) (Paraffin) |
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| MBS639459-5Arrays | MyBiosource | 5Arrays | EUR 765 |
Tissue, Array, Human Tumor, Different Types of Tumor, Multi, tissue III (5), kidney, control, lung, control, normal placenta (matched with mRNA blots) (Paraffin) |
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| MBS639459-5x5Arrays | MyBiosource | 5x5Arrays | EUR 3300 |
Multiple sarcoma of soft tissue array with normal tissue |
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| SO208a | TissueArray | each | EUR 546 |
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Description: Multiple sarcoma of soft tissue array with normal tissue, including pathology grade, TNM and clinical stage, 64 cases/192 cores, replacing SO208 |
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Multiple organ cancer with normal tissue array |
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| BCN601a | TissueArray | each | EUR 270 |
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Description: Multiple organ cancer with normal tissue array, including pathology grade, TNM and clinical stage, 60 cases/60 cores, replacing BCN601 |
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Normal female dog multiple organs tissue array |
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| DGF281 | TissueArray | each | EUR 306 |
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Description: Normal female dog multiple organs tissue array, 28 organs/ 28cores |
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Kidney cancer with kidney tissue test tissue array |
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| T071b | TissueArray | each | EUR 48 |
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Description: Kidney cancer with kidney tissue test tissue array, including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T071a |
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Multiple cervix cancer with cervix tissue array |
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| CR1001b | TissueArray | each | EUR 270 |
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Description: Multiple cervix cancer with cervix tissue array, including pathology grade, TNM and clinical stage, 50 cases/100 cores, replacing CR1001a |
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Multiple breast cancer with breast tissue array |
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| BR087e | TissueArray | each | EUR 48 |
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Description: Multiple breast cancer with breast tissue array, including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing BR087d |
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Multiple lung carcinoma and normal tissue array |
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| LC2082 | TissueArray | each | EUR 546 |
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Description: Multiple lung carcinoma and normal tissue array, 70 cases/208 cores |
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Kidney cancer tissue array |
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| BC07014b | TissueArray | each | EUR 168 |
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Description: Kidney cancer tissue array, including pathology grade, TNM and clinical stage, 72 cases/72 cores, replacing BC07014a |
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Kidney cancer tissue array |
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| KD245 | TissueArray | each | EUR 66 |
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Description: Kidney cancer tissue array, including TNM, clinical stage and pathology grade, 24 cases/ 24 cores |
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Kidney cancer tissue array |
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| KD485 | TissueArray | each | EUR 168 |
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Description: Kidney cancer tissue array, with normal tissue, including TNM and pathology grade, 48 cases/48 cores |
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Normal kidney tissue array |
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| KD803 | TissueArray | each | EUR 354 |
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Description: Normal kidney tissue array, replacing BN07012, 80 cases/80 cores |
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Normal kidney tissue array |
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| KDN242 | TissueArray | each | EUR 72 |
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Description: Normal kidney tissue array, 24 cases/24 cores |
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Kidney cancer tissue array with normal Kidney tissue |
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| KD2082a | TissueArray | each | EUR 474 |
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Description: Kidney cancer tissue array with normal Kidney tissue, including TNM and pathology grade, 96 cases/192 cores, replacing KD2082 |
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Multiple organ blastoma with normal tissue array |
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| MC809b | TissueArray | each | EUR 414 |
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Description: Multiple organ blastoma with normal tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores, replacing MC809a |
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Multiple lymphoma tissue array with normal tissue as control |
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| LM481c | TissueArray | each | EUR 198 |
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Description: Multiple lymphoma tissue array with normal tissue as control, 48 cases/ 48 cores (core size 1.5mm), replacing LM481a |
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Multiple lung cancer tissue array (2015 WHO classification) |
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| LC1501 | TissueArray | each | EUR 258 |
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Description: Multiple lung cancer tissue array (2015 WHO classification), including pathology grade, TNM and clinical stage, 75 cases/150 cores |
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Multiple stomach cancer with stomach tissue array |
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| ST2161b | TissueArray | each | EUR 546 |
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Description: Multiple stomach cancer with stomach tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 216 cases/216 cores, replacing ST2161a |
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Multiple organ cancer tissue array with adjacent normal tissue |
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| BC01071b | TissueArray | each | EUR 168 |
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Description: Multiple organ cancer tissue array with adjacent normal tissue, including pathology grade, TNM and clinical stage, 48 cases/48 cores, replacing BC01071a |
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Multiple organ squamous cell carcinoma tissue array |
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| BC00019 | TissueArray | each | EUR 270 |
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Description: Multiple organ squamous cell carcinoma tissue array, 63 cases/63 cores |
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Multiple organ squamous cell carcinoma tissue array |
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| MC632 | TissueArray | each | EUR 270 |
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Description: Multiple organ squamous cell carcinoma tissue array, including pathology grade, TNM and clinical stage, 63 cases/63 cores (core size 1.5mm), replacing BC00019 |
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FDA multiple organ normal tissue array of rhesus |
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| RhFDA1a | TissueArray | each | EUR 306 |
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Description: FDA multiple organ normal tissue array of rhesus, 8 case/31 organs/99 cores, replacing RhFDA1 |
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Bovendien gaf nuttige evaluatie aan dat SOX9-silencing de bolvormingsfunctionaliteit van HCT116-cellen aanzienlijk verzwakte. Het huidige onderzoek was de eerste om de expressiebereiken van SOX9 te beoordelen bij Mexicaanse patiënten die werden geïdentificeerd met CC in een vroeg stadium. De bovengenoemde bevindingen gaven aan dat primaire SOX9-expressie een essentiële functie kan spelen bij tumorgenese en gerelateerd kan zijn aan superieure T-stadia van patiënten met klinisch stadium II, maar niet met terugvalvrije overleving.
