PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Papillary Renal Cell Carcinoma

PTP4A3 vervult een essentiële functie binnen de tumorvorming en metastase van een aantal tumoren , maar de prognostische functie ervan bij de meeste nierkankers zal niet effectief worden begrepen. We gebruik gemaakt van de Oncomine en Tumor Immunoassay Nuttig resource databases te kijken naar de differentiële expressie van PTP4A3 in tumor weefsels en regelmatige weefsels in de borst, urinewegen, maagdarmkanaal en poriën en de huid.

Gebruik makend van de GEPIA en PrognoScan databases, de onpartijdige prognostische functie van PTP4A3 werd bevestigd in clear cell niercelcarcinoom meeste vormen van kanker en papillaire niercelkanker meeste vormen van kanker . Expressie van PTP4A3 was duidelijk groter in tumorweefsel , te evalueren met reguliere weefsels ( P = 0,028).

We hebben de associaties van PTP4A3 en klinisch-pathologische opties niet ontdekt in ons IHC- cohort. Ectopische expressie van PTP4A3 bevordert proliferatie, migratie en invasie en verhoogde het mRNA-stadium van TGFB1 in RCC-celstammen.

Immunohistochemische kleuring gaf aan dat de expressie van PTP4A3 associeert met CD3 + ( P = 0,037) / CD8 + ( P = 0,037) intra tumor TIL, niet met invasieve marges renale kanker . Volledige evaluatie van immuuninfiltratie in de TIMER-database correleerde PTP4A3-expressie met de infiltratie van B-cellen, CD8+ T-cellen, CD4+ T- cellen en neutrofielen in elk heldercellig niercelcarcinoom en papillair niercelcarcinoom.

PTP4A3-expressie was gerelateerd aan de infiltratie van dendritische cellen in papillair niercelcarcinoom. We bevestigden bovendien dat de infiltratie van B-cellen en CD8+ T-cellen gerelateerd was aan een slechte prognose bij patiënten met papillair niercelcarcinoom, in overeenstemming met de prognostische functie van PTP4A3 bij papillair niercelcarcinoom.

PTP4A3-expressie correleerde genen in B-cellen, monocyten, M1-macrofagen, Th2- en Treg-cellen in papillair niercelcarcinoom. Deze uitkomsten raden PTP4A3 aan als een prognostische kwestie met een baan bij het reguleren van de infiltratie van immuuncellen bij papillair niercelcarcinoom.

hnRNPA2B1 bevordert de dikke darm De meeste kankers Ontwikkeling via de MAPK-route

HNRNPA2B1, een RNA bindend eiwit, vervult een belangrijke functie in grote microRNA verwerking, verschillende splicing, mRNA metabolisme en transport. Merkwaardig , hnRNPA2B1 bovendien werkt als N6-methyladenosine (M6A) lezer en is essentieel gedurende tumorgenese van diverse weefsels variëteiten .

Niettemin , zijn functie in de dikke darm kanker blijft onduidelijk. Bij dit onderzoek wilden we de organische mogelijkheden van hnRNPA2B1 ophelderen en de onderliggende mechanismen ervan ontdekken bij de meeste kankers in de dikke darm . We onderzochten de expressie van hnRNPA2B1 in Oncomine- en TCGA-databases.

Verifieerde vervolgens de bevindingen in de meeste kankercellen van de dikke darm en medische monsters met western blotting en immunohistochemie ( IHC ). We gebruikten CRISPR / Cas9 gerichte gen verhogen knockout hnRNPA2B1 expressie in humane colon kanker cellijn SW480 en HCT-116 en uitgevoerd elke in vivo en in vitro experimenten. De resultaten zijn bovendien bevestigd door RNA-seq-analyses.

We ontdekten dat hnRNPA2B1 aanzienlijk bevorderd dikke darm kanker celproliferatie elk in vitro en in vivo , terwijl knock-out van hnRNPA2B1 geïnduceerde apoptose en celcyclus arrestatie in SW480. RNA-seq-analyses onthulden dat de ERK / MAPK-route werd geactiveerd door hnRNPA2B1-upregulatie.

Naast , elke hnRNPA2B1 en MAPK route is geactiveerd medische colon kanker specimens en positief gecorreleerd. Mechanistisch gezien leek hnRNPA2B1 een stroomopwaartse regulator van de ERK/MAPK-route te zijn en remming van MAPK-signalering blokkeerde de gevolgen van hnRNPA2B1.

Taken collectief , onze gegevens blijkt dat de RNA-bindende eiwit hnRNPA2B1 stimuleert celproliferatie en reguleert celcyclus en apoptose van menselijke colon kanker door activering van de ERK / MAPK -signalering, die presenteren een nieuwe waarneming in geval van hnRNPA2B1 als een mogelijke therapeutisch doel voor de remedie van de meeste kankers van de dikke darm .

Metaplastisch borstcarcinoom: klinisch-pathologische parameters en prognostisch profiel

Inleiding Metaplastisch borstcarcinoom (MBC) wordt geschetst als de meeste borstkankers met een heteroloog niet-glandulair element . MBC houdt rekening met een bepaald soort borstkanker, de meeste kankers met een prognose die slechter is dan invasief ductaal carcinoom (IDC) van de borst. MBC is de meest typische borsten meeste vormen van kanker met een triple-negatieve profiel.

Vanwege dit feit , op deze onderzoeken , evalueerden we tot de klinische parameters, herhaling en overleving van MBC in onze inwoners . Strategieën We voerden een retrospectief observationeel onderzoek uit binnen de afdeling Histopathologie van het Prince Faisal Oncology Centre, Buraidah, Saoedi-Arabië, over een interval van 5 jaar.

Alle omstandigheden geïdentificeerd als MBC zijn opgenomen in het te onderzoeken . Oestrogeenreceptor (ER), progesteronreceptor (PR) en epidermale humane ontwikkeling probleem receptor 2 (HER2 / neu) immunohistochemie ( IHC ) werd uitgevoerd op consultant weefsel blokken. Uitkomsten Whole 183 omstandigheden van MBC’s zijn opgenomen in het onderzoek , waarvan 120 omstandigheden zijn excisie specimens.

De impliciete leeftijd van de patiënten was 48,84 ± 12,99 jaar, en de meest typische leeftijdsgroep was tussen 36 en 50 jaar. Veel van de omstandigheden waren tumor (T) stadium T3 (50%), en nodale metastase was actueel in 40% van de omstandigheden .

De meeste omstandigheden waren graad III (78,7%). ER-, PR- en HER2/neu-positiviteit was beroemd in respectievelijk 15,8%, 13,1% en 9,8%. Observatie-informatie is al 70 omstandigheden beschikbaar, met een mediane follow-up-interval van 4 (1-7) jaar. Tumorrecidief was beroemd in 31,4% omstandigheden, met een overlevingspercentage van 71,4%. Plaveiselcel, chondroïde, spilceldifferentiatie en matrixproductie zijn beroemd in respectievelijk 70,5%, 7,1%, 13,7% en een paar,2% omstandigheden.

Een belangrijke verwantschap van squameuze differentiatie was beroemd met HER2 / neu-positiviteit. Een omgekeerde verwantschap van spilceldifferentiatie werd gezien bij okselmetastasen. Survival evaluatie door Kaplan-Meier onthulde een grote aansluiting van de overleving met tumor recidief.

Conclusie MBC is een essentieel subtype van de meeste borstkankers , waarvan histopathologische identificatie moeilijk is vanwege verschillende histologische differentiatie. We ontdekten dat squameuze differentiatie de meest typische is in MBC, wat gerelateerd was aan HER2 / neu-positiviteit. Een buitensporig recidief van MBC werd bovendien opgemerkt in ons onderzoek dat aanzienlijk verband hield met overleving.

SOX9 is gerelateerd aan superieure T-stadia van medisch stadium II colon, de meeste kankers bij jongere Mexicaanse patiënten

De meeste colorectale kankers (CRC) is zonder twijfel een van de meest voorkomende maligniteiten ter wereld en bevat de meeste kankers van de dikke darm (CC) en de meeste rectale kankers (RC). Betreffende CC geval van nieuwe moleculaire biomarkers voor correcte analyse en prognose, naast de identificatie van nieuwe doelwitten voor therapeutische interventie, dringend gezocht .

SRY-verwante groep hoge mobiliteit veld 9 (SOX9), een transcriptie probleem wordt betrokken bij groei , en is gerelateerd aan de ontwikkeling van humane kanker . Niettemin , de onderliggende medische en bruikbare resultaten in CRC niet zijn helemaal begrepen. Vanwege dit feit was het huidige onderzoek gericht op het beoordelen van de medische en bruikbare relevantie van SOX9-expressie in CC.

De expressie van SOX9 in tumor weefsel werd geëvalueerd in 97 biopten van Mexicaanse patiënten met CC met een vroeg stadium I en II ziekte door middel van immunohistochemie ( IHC ). Evenals werd SOX9-silencing binnen de HCT116-cellijn uitgevoerd met behulp van bepaalde kleine interfererende RNA’s, terwijl de effectiviteit van de neerwaartse regulatie werd geverifieerd door reverse transcriptie-kwantitatieve PCR en immunofluorescentie.

Sferoïde-vormingstest werd uitgevoerd met behulp van ultra-lage bevestigingsplaten. De IHC- resultaten bevestigden dat SOX9 was opgereguleerd bij patiënten met stadium II (91%) en superieure T3-stadium (67%) CC. Merkwaardig , groter is SOX9 expressie betrekking op medische stadium tumor meet- en tumor locatie. Bovendien was verhoogde SOX9-expressie aanwezig in recidiverende omstandigheden met inheemse tumoren ; niettemin , Het was niet gerelateerd aan een verhoogde overleving waarschijnlijkheid .

Multiple Species Paraffin Tissue Array - Liver
T8134149-5	Biochain	5 slides	EUR 450
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - Ovary, Bladder, Breast, Kidney, Uterus, and Lung tumors, plus 12 tumor/normal pairs
T8235714d-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - Ovary, Bladder, Breast, Kidney, Uterus, and Lung tumors, plus 12 tumor/normal pairs
T8235714d-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - Kidney, Colon, Esophagus, Liver, Rectum and Stomach tumors, plus 12 tumor/normal pairs
T8235715d-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - Kidney, Colon, Esophagus, Liver, Rectum and Stomach tumors, plus 12 tumor/normal pairs
T8235715d-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - Bladder, Colon, Kidney, Lung, Stomach, and Uterus tumors, plus 12 tumor/normal pairs
T8235716d-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Kidney Tumor Tissue Array - 12 cases of kidney cancer paired with adjacent normal tissues
Z7020053	Biochain	5 slides	EUR 938
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Kidney Tumor Tissue Array - 48 cases of uninvolved and cancerous tissues of the kidney in duplicates
Z7020055	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - 24 duplicated cases of gastrointestinal stroma tumor with various grades and stages.
Z7020038	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Human, Mouse, Rat - Kidney Tissue Array (5 slides/pk)
TAS-1008	Alpha Diagnostics	1 pk	EUR 286

cDNA from Human Tumor Tissue: Kidney
C1235142	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Frozen Tissue Section - Human Tumor: Kidney
T1235142	Biochain	5 slides	EUR 338
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Kidney Tumor
T2235142	Biochain	5 slides	EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - 12 major types of cancer paired with adjacent normal tissues
Z7020080	Biochain	5 slides	EUR 938
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Kidney Tumor: Wilms' Tumor
T2235142-7	Biochain	5 slides	EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Human Tumor and Normal Tissue, Multi-tissue I
T6235700-1	Biochain	1 slide	EUR 412
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Human Tumor and Normal Tissue, Multi-tissue I
T6235700-5	Biochain	5 slides	EUR 1168
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - 15 different tumors and their corresponding normal tissues spotted in duplicate
T8235712-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - 15 different tumors and their corresponding normal tissues spotted in duplicate
T8235712-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Membrane Protein from Human Tumor Tissue: Kidney
P3235142	Biochain	0.1 mg	EUR 408
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Tumor Tissue: Kidney
P1235142	Biochain	1 mg	EUR 320
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Human Tumor Tissue: Kidney
R1235142-50	Biochain	50 ug	EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Multiple Tumor Tissue Array - 47 different tumors and their corresponding normal tissues, plus 2 control spots
T8235713-2	Biochain	2 slides	EUR 391
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - 47 different tumors and their corresponding normal tissues, plus 2 control spots
T8235713-5	Biochain	5 slides	EUR 910
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - Duplicated 48 cases of benign and malignant tumors of the nervous system
Z7020084	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Tissue Array
T8234701-1	Biochain	1 slides	EUR 214
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Tissue Array
T8234701-5	Biochain	5 slides	EUR 654
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - 15 major types tumors. Most types have duplicates from different patients with correspondi
Z7020081	Biochain	5 slides	EUR 938
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - 7 different normal tissues and 5 major tumor types in duplicates for IHC antibody and ISH
Z7020079	Biochain	5 slides	EUR 268
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Kidney Tumor Tissue Array - Duplicated 70 cases covering all the common types of kidney cancer and 5 cases of normal and
Z7020052	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Kidney Tumor Tissue Array - Duplicated 36 cases covering all the common types of kidney cancer and 12 cases of normal an
Z7020054	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Bladder Tumor Tissue Array - 12 cases of bladder tumor/adjacent normal pairs
Z7020105	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - 37 Different Kidney Tumors and 3 Corresponding Normal Controls
T6235142-1	Biochain	1 slide	EUR 654
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - 37 Different Kidney Tumors and 3 Corresponding Normal Controls
T6235142-5	Biochain	5 slides	EUR 2034
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Matched Pair (Normal and Carcinoma) Human Kidney Tissue Array (5 slides/pk)
TAS-1007	Alpha Diagnostics	1 pk	EUR 286

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)
T8234708-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section Array - Human Adult Normal Tissue, Array I (64 Specimens)
T8234708-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Multiple Tumor Tissue Array - 40 types of tumors. Most of them have duplicates or triplicates from different individual
Z7020082	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Kidney Tumor: Clear cell carcinoma
T2235142-2	Biochain	5 slides	EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Kidney Tumor: Renal Cell Carcinoma
T2235142-5	Biochain	5 slides	EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Human Cancer Tissue Preparation Buffer 9: Kidney Tumor Cells
9-80032	CHI Scientific	1 x 100 ml	Ask for price

Human Kidney Tissue Lysate
30R-AK003	Fitzgerald	150 ug	EUR 219
Description: Fresh tissue lysate isolated from human kidney

Rat Kidney Tissue Lysate
LYSATE0006	BosterBio	200ug	EUR 150
Description: This cell lysate is prepared from rat kidney tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Mouse Kidney Tissue Lysate
LYSATE0016	BosterBio	200ug	EUR 150
Description: This cell lysate is prepared from mouse kidney tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Genomic DNA from Human Tumor Tissue: Kidney Tumor, from a single donor
D1235142	Biochain	50 ug	EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Multiple Tumor Tissue Array - 12 types of human tissues in duplicates, designed as universal control for >90% routine IH
Z7020083	Biochain	5 slides	EUR 268
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Human Adult Normal Tissue, Multi-tissue I
T6234700-1	Biochain	1 slide	EUR 281
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Human Adult Normal Tissue, Multi-tissue I
T6234700-5	Biochain	5 slides	EUR 927
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Human Kidney Tumor lysate
HTL-1324	Alpha Diagnostics	1 mg	EUR 773

Paraffin Tissue Section - Human Kidney Tumor: Papillary Renal Cell Carcinoma
T2235142-4	Biochain	5 slides	EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Diabetic Tissue: Kidney
T1236142Dia	Biochain	5 slides	EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Dog Male Adult Normal Tissue, Multi-tissue I
T6734700-G01-1	Biochain	1 slide	EUR 258
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Dog Male Adult Normal Tissue, Multi-tissue I
T6734700-G01-5	Biochain	5 slides	EUR 821
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Dog Female Adult Normal Tissue, Multi-tissue I
T6734700-G02-1	Biochain	1 slide	EUR 258
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Dog Female Adult Normal Tissue, Multi-tissue I
T6734700-G02-5	Biochain	5 slides	EUR 821
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I
T6834700-G01-1	Biochain	1 slide	EUR 258
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I
T6834700-G01-5	Biochain	5 slides	EUR 821
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I
T6834700-G02-1	Biochain	1 slide	EUR 258
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I
T6834700-G02-5	Biochain	5 slides	EUR 821
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Kidney
T1236142Hd-2	Biochain	5 slides	EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Kidney
T1236142Lup	Biochain	5 slides	EUR 534
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Lupus: Kidney
T2236142Lup	Biochain	5 slides	EUR 249
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Rat Kidney Medulla Tissue Lysate
30R-AK004	Fitzgerald	150 ug	EUR 192
Description: Fresh tissue lysate isolated from the medulla of rat kidney

Mouse Kidney Whole tissue lysate
MAL-1405	Alpha Diagnostics	1 mg	EUR 524

Rat Kidney Whole tissue lysate
RAL-1465	Alpha Diagnostics	1 mg	EUR 524

Matching Pair - Total Protein from Human Primary Tumor and Metastatic Tumor Tissue (PM): Kidney
P8235142-PM	Biochain	0.2 mg x2	EUR 1228
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Matching Pair - cDNA from Human Primary Tumor and Normal Tissue: Kidney
C8235142-PP	Biochain	10 reactions x2	EUR 499
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Matching Pair - DNA from Human Primary and Metastatic Tumor Tissue: Kidney
D8235142-PM-10	Biochain	2x10 ug	EUR 610
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Matching Pair - DNA from Human Primary Tumor and Normal Tissue: Kidney
D8235142-PP-10	Biochain	2x10 ug	EUR 387
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FDA Standard Frozen Tissue Array - Mouse Normal
T6334701-1	Biochain	2 slides	EUR 599
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Frozen Tissue Array - Mouse Normal
T6334701-2	Biochain	4 slides	EUR 1041
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Frozen Tissue Array - Rat Normal
T6434701-1	Biochain	2 slides	EUR 599
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Frozen Tissue Array - Rat Normal
T6434701-2	Biochain	4 slides	EUR 1041
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Metastatic Tumor Tissue Array - 18 cases of metastatic cancers from 4 anatomic sites
Z7020073	Biochain	5 slides	EUR 938
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Metastatic Tumor Tissue Array - 48 cases of metastatic cancers from 8 anatomic sites
Z7020074	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Stomach Tumor Tissue Array - 16 cases of gastric cancer, each in duplicates, paired with corresponding uninvolved tissue
Z7020031	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Lung Tumor Tissue Array - 7 types, 15 cases of normal, inflammatory and tumor tissues of the lung.
Z7020068	Biochain	5 slides	EUR 938
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Testis Tumor Tissue Array - 16 cases of testis tumors and 8 cases of non-tumor testis tissues.
Z7020096	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Matching Pair - cDNA from Human Primary and Matched Metastatic Tumor Tissue: Kidney
C8235142-PM	Biochain	10 reactions x2	EUR 984
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Matching Pair - Frozen Tissue Section - Human Primary Tumor and Normal (PP): Kidney
T6235142-PP	Biochain	5 slides x2	EUR 599
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Matching Pair - Paraffin Tissue Section - Human Primary Tumor and Normal (PP): Kidney
T8235142-PP	Biochain	5 slides x2	EUR 403
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Matching Pair - Total RNA from Human Primary and Metastatic Tumor Tissue: Kidney
R8235142-PM-10	Biochain	2x10 ug	EUR 650
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Matching Pair - Total RNA from Human Primary Tumor and Normal Tissue: Kidney
R8235142-PP-10	Biochain	2x10 ug	EUR 439
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

cDNA from Human Diabetic Tissue: Kidney
C1236142Dia	Biochain	40 reactions	EUR 668
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Kidney
C1334142	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Kidney
C1434142	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Kidney
C1734142	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Paraffin Tissue Section - Liver Cirrhosis: Kidney
T2236142Lcs	Biochain	5 slides	EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Human Kidney OptiTDS1: Tissue Dissociation System
4-28074	CHI Scientific	1 Kit	Ask for price

Human Kidney OptiTDS2: Tissue Dissociation System
4-28075	CHI Scientific	1 Kit	Ask for price

Human Kidney OptiTDS3: Tissue Dissociation System
4-28076	CHI Scientific	1 Kit	Ask for price

Human Kidney OptiTDS4: Tissue Dissociation System
4-28077	CHI Scientific	1 Kit	Ask for price

Human Kidney OptiTDS5: Tissue Dissociation System
4-28078	CHI Scientific	1 Kit	Ask for price

Human Kidney OptiTDS6: Tissue Dissociation System
4-28079	CHI Scientific	1 Kit	Ask for price

Human Kidney OptiTDS7: Tissue Dissociation System
4-28080	CHI Scientific	1 Kit	Ask for price

Mouse Kidney OptiTDS1: Tissue Dissociation System
4-28170	CHI Scientific	1 Kit	Ask for price

Mouse Kidney OptiTDS2: Tissue Dissociation System
4-28171	CHI Scientific	1 Kit	Ask for price

Mouse Kidney OptiTDS3: Tissue Dissociation System
4-28172	CHI Scientific	1 Kit	Ask for price

Mouse Kidney OptiTDS4: Tissue Dissociation System
4-28173	CHI Scientific	1 Kit	Ask for price

Mouse Kidney OptiTDS5: Tissue Dissociation System
4-28174	CHI Scientific	1 Kit	Ask for price

Mouse Kidney OptiTDS6: Tissue Dissociation System
4-28175	CHI Scientific	1 Kit	Ask for price

Mouse Kidney OptiTDS8: Tissue Dissociation System
4-28177	CHI Scientific	1 Kit	Ask for price

Rat Kidney OptiTDS1: Tissue Dissociation System
4-28262	CHI Scientific	1 Kit	Ask for price

Rat Kidney OptiTDS2: Tissue Dissociation System
4-28263	CHI Scientific	1 Kit	Ask for price

Rat Kidney OptiTDS5: Tissue Dissociation System
4-28266	CHI Scientific	1 Kit	Ask for price

Rat Kidney OptiTDS6: Tissue Dissociation System
4-28267	CHI Scientific	1 Kit	Ask for price

Rat Kidney OptiTDS8: Tissue Dissociation System
4-28269	CHI Scientific	1 Kit	Ask for price

Human Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells
9-80075	CHI Scientific	1 x 100 ml	Ask for price

Mouse Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells
9-80171	CHI Scientific	1 x 100 ml	Ask for price

Rat Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells
9-80263	CHI Scientific	1 x 100 ml	Ask for price

Breast Tumor Tissue Array - 64 Different Breast tumors. Plus positive control and negative control
T8235721-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Breast Tumor Tissue Array - 64 Different Breast tumors. Plus positive control and negative control
T8235721-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Colon Tumor Tissue Array - 64 Different Colon tumors. Plus positive control and negative control
T8235722-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Colon Tumor Tissue Array - 64 Different Colon tumors. Plus positive control and negative control
T8235722-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Rectum Tumor Tissue Array - 64 Different Rectum tumors. Plus positive control and negative control
T8235723-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Rectum Tumor Tissue Array - 64 Different Rectum tumors. Plus positive control and negative control
T8235723-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Lung Tumor Tissue Array - 64 Different Lung tumors. Plus positive control and negative control
T8235724-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Lung Tumor Tissue Array - 64 Different Lung tumors. Plus positive control and negative control
T8235724-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Ovary Tumor Tissue Array - 64 Different Ovary tumors. Plus positive control and negative control
T8235725-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Ovary Tumor Tissue Array - 64 Different Ovary tumors. Plus positive control and negative control
T8235725-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Cervical Tumor Tissue Array - 12 cases of cervical cancer paired with adjacent normal tissues
Z7020014	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Endometrial Tumor Tissue Array - 12 cases of endometrial cancer paired with adjacent normal tissues
Z7020023	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Ovary Tumor Tissue Array - 12 cases of ovary cancer paired with adjacent normal tissues
Z7020087	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Multiple Sclerosis Disease: Brain
T1236035Msc	Biochain	5 slides	EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain
T2236035Msc	Biochain	5 slides	EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Frozen Tissue Array - Human Adult Normal
T6234701-1	Biochain	2 slides	EUR 1120
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

FDA Standard Frozen Tissue Array - Human Adult Normal
T6234701-2	Biochain	4 slides	EUR 2034
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Colon Tumor Matching Pair Tissue Array - 29 colon tumor/adjacent normal pairs. Plus positive control and negative control
T8235790D-2	Biochain	2 slides	EUR 307
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Colon Tumor Matching Pair Tissue Array - 29 colon tumor/adjacent normal pairs. Plus positive control and negative control
T8235790D-5	Biochain	5 slides	EUR 579
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Head & Neck Tumor Tissue Array - 48 cases of inflammatory, benign and malignant tumor tissues of the neck, oranasopharyn
Z7020051	Biochain	5 slides	EUR 1381
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Bovendien gaf nuttige evaluatie aan dat SOX9-silencing de bolvormingsfunctionaliteit van HCT116-cellen aanzienlijk verzwakte. Het huidige onderzoek was de eerste om de expressiebereiken van SOX9 te beoordelen bij Mexicaanse patiënten die werden geïdentificeerd met CC in een vroeg stadium. De bovengenoemde bevindingen gaven aan dat primaire SOX9-expressie een essentiële functie kan spelen bij tumorgenese en gerelateerd kan zijn aan superieure T-stadia van patiënten met klinisch stadium II, maar niet met terugvalvrije overleving.