Het remmende effect en mechanisme van quetiapine op tumorprogressie bij hepatocellulair carcinoom in vivo

Hepatocellulair carcinoom (HCC) is de eerste tumor van de lever en de vierde belangrijkste reden achter de meeste aan kanker gerelateerde overlijdens. Nog niet zo lang geleden wees een aantal onderzoeken op het antitumorpotentieel van antipsychotica. Quetiapine, een atypisch antipsychoticum, wordt sinds 1997 gebruikt voor de behandeling van schizofrenie, bipolaire stoornissen en depressieve stoornissen.

Desalniettemin is het nog steeds onduidelijk of quetiapine de ontwikkeling van HCC kan onderdrukken en of het onderliggende mechanisme ervan kan worden onderdrukt. Het is bewezen dat quetiapine in vitro apoptose induceert en de invasievaardigheid in HCC remt. Hier hebben we twee totaal verschillende HCC (Hep3B, SK-Hep1) dragende dieren vastgesteld om de therapie-effectiviteit van quetiapine te bepalen.

Tumorprogressie , signaaltransductie en reguliere weefselpathologie na behandeling met quetiapine zijn gevalideerd door respectievelijk schuifmaat, bioluminescentiebeeld, immunohistochemie ( IHC ) en hematoxyline- en eosinekleuring. Quetiapine onderdrukte de HCC-ontwikkeling op een dosisafhankelijke methode.

Extracellulaire signaalgereguleerde kinasen (ERK’s) en door kernfactor-KB (NF-KB) gemedieerde stroomafwaartse eiwitten, vergelijkbaar met myeloïde leukemieceldifferentiatie-eiwit (MCL-1), mobiel FLICE-remmend eiwit (C-FLIP), X-gekoppelde remmer van apoptose-eiwit (XIAP), Cyclin-D1, matrix metallopeptidase 9 (MMP-9) , vasculaire endotheliale progressiefactor-A (VEGF-A) en indoleamine 2,3-dioxygenase (IDO) die betrekking hadden op proliferatie, overleving, angiogenese, invasie en antitumorimmuniteit zijn allemaal verminderd door quetiapine.

Daarnaast zijn extrinsieke/intrinsieke caspase-afhankelijke en caspase-onafhankelijke routes, samen met gesplitste caspase-3, -8 en – 9 verhoogd door quetiapine. Kortom, de tumor remmen die uitkomsten van quetiapine lid kon met ERK en NFKB inactivatie.

Afwijkende expressie van MYD88 door middel van RNA-controlerende CNOT4 en EXOSC3 in colonmucosa heeft invloed op de technologie van de meeste kankers in de dikke darm

In 2020, de wereldwijde incidentie en mortaliteit van colorectale kanker (CRC) zijn derde tweede, respectievelijk. Omdat de vijf jaar te overleven prijs is laag wanneer CRC wordt geïdentificeerd in een ingewikkeld stadium, een betrouwbare techniek te voorspellen CRC gevoeligheid is van essentieel belang voor het stoppen van het ontstaan en de groei en het verbeteren van de prognose van de CRC.

Vervolgens hebben we ons geconcentreerd op het conventionele colonmucosa om veranderingen in genexpressie te onderzoeken die daaropvolgende genetische veranderingen zullen induceren die kwaadaardige transformatie induceren. Volledige genexpressie profilering in de normale mucosa grenzend aan colon kanker (CC) vergeleken met weefsel van noncolon kanker (NCC) patiënten werd uitgevoerd .

PCR-arrays en qRT-PCR onthulden dat de expressie van 5 genen die betrokken zijn bij de immuunrespons, samen met MYD88, verhoogd was in het reguliere slijmvlies van CC- patiënten . De expressie varieert van MyD88 zijn opvallend verhoogd pre kanker ous normale mucosa specimens, waarvoor geen somatische mutaties herbergden, zoals aangetoond door immunohistochemie ( IHC ).

Microarray evaluatie herkende twee nieuwe RNA-moleculen regelen, EXOSC3 en CNOT4, die zijn aanzienlijk opwaarts gereguleerd binnen het normale slijmvlies van CC patiënten en zijn duidelijk zichtbaar in de kernen.

Gedwongen expressie van EXOSC3 en CNOT4 in menselijke colonepitheelcellen verhoogde de expressie van IFNGR1, MYD88, NFκBIA en STAT3 en activeerde ERK1/2 en JNK in 293T-cellen. Genomen collectief , deze uitkomsten raadsman dat binnen de geïnfecteerde slijmvlies, EXOSC3- en CNOT4-gemedieerde RNA stabilisatie, samen met die van MyD88, kon verrekenen het geval van de meeste vormen van kanker en kan functioneren een mogelijke voorspellende marker en revolutionaire therapie voor het beheer van de meeste vormen van kanker groei .

Fluorescerende multiplex-immunohistochemie in combinatie met verschillende ultramoderne methoden om de tumor- immuunmicro-omgeving systematisch te karakteriseren

Onze het verhogen van informatie van de interacties tussen tumor cellen en hun micro-omgeving heeft geholpen om een revolutie meeste vormen van kanker remedies , samen met de nieuwere groei van immuuntherapie. Immuuncellen zijn een essentieel onderdeel van de micro-omgeving van de tumor die de ontwikkeling en therapieresponsen beïnvloeden, met name op de gloednieuwe immunotherapieën.

Technologische vooruitgang die helpen om de complexiteit te ontcijferen en de verscheidenheid van de tumor immuun micro-omgeving (TIME) zijn meer en meer gebruikt in translationeel onderzoek en biomarker onderzoek . Huidige methoden die TIME- analyse vergemakkelijken , omvatten circulerende cytometrie, op multiplex gebaseerde immunoassays, chromogene immunohistochemie ( IHC ), fluorescerende multiplex IHC , immunofluorescentie en ruimtelijke transcriptomics.

Deze tekst geeft een samenvatting van onze consultant informatie , bespreekt het apparaat van elke strategie om het onderzoek van de tijd, samen met hun voordelen en uitdagingen, en adviezen van het potentieel wetenschappelijke doeleinden . Move cytometry en chromogene en fluorescerende multiplex IHC zijn gebruikt om het immuunsysteem profiel een HER2 + borstkanker meeste vormen van kanker , ter illustratie van een aantal factoren .

Ruimtelijke transcriptoom evaluatie van een luminale B borst tumor aangetoond dat essentiële verder perceptie kan worden opgedaan met deze nieuwe methode . Tenslotte , indien van multiplex paneel om te bepalen prolifererende B-cellen, Tfh en Tfr cellen op de identieke weefsel gedeelte toont de co-localisatie in tertiaire lymfoïde gebouwen .

Incidentie van schildkliercarcinomen in een langdurig retrospectief onderzoek van 526 autopsies

Schildklier meeste vormen van kanker is goed voor 1% van alle maligniteiten, en veranderen in meer en meer verspreid over de hele wereld. De literatuur vermeldt een prevalentie van ~50% van de schildklierknobbeltjes die werden gedetecteerd tijdens autopsies bij onderwerpen met onbekende schildklierpathologie.

Een langdurig retrospectief onderzoek van 526 postmortale gevallen werd uitgevoerd om de prevalentie van schildkliercarcinoom te bepalen , onder de talrijke vormen van schildklierknobbeltjes die overigens worden herkend . Tissue monsters zijn genomen van schildklier knobbeltjes, voor onderzoek naar de aanwezigheid van schildkliercarcinoom, samen met hun macroscopische en microscopische opties via histopathologie en immunohistochemie ( IHC ) strategieën .

Histopathologische analyse van maligniteit was aanwezig in 51 gevallen van geanalyseerde schildkliermonsters. Systematisch gedetailleerd onderzoek toonde aan {dat een} schildklier, schijnbaar regelmatig bij macroscopisch onderzoek, de website zal zijn van pathologische manifestaties, die typisch carcinomateuze bevindingen presenteren.

Onder schildkliercarcinomen was de allerbeste frequentie die van papillaire microcarcinomen, die een langdurige evolutie hebben en trouwens worden gedetecteerd tijdens autopsies. Papillair microcarcinoom is een bijzonder wijdverbreide incidentele ontdekking en de overgrote meerderheid van die tumoren volgt een goedaardig verloop. Bovendien , is het gevolg van dit feit essentieel maken landelijke screening aanvragen voor de vroegtijdige detectie van schildkliercarcinoom.

NOL4L, een nieuw nucleair eiwit, bevordert celproliferatie en metastase door de PI3K/AKT-route bij de meeste eierstokkankers te verbeteren

Nucleolair eiwit 4-achtig (NOL4L) werd voor het eerst herkend bij acute myeloïde leukemie. Daarna werd het gecontroleerd te worden betrokken in cel ontwikkeling in neuroblastoom. Desalniettemin worden de praktische positie van NOL4L in tumorproliferatie en metastase en de onderliggende moleculaire mechanismen meestal niet volledig begrepen.

Immunohistochemie ( IHC ) testen zijn uitgevoerd in weefsels van aangetaste personen om NOL4L-expressieprofielen te onthullen . Dan hebben we neergehaald NOL4L twee ovariële kanker cel stammen (SKOV3-IP1 en He) en cellen gebaseerde in vitro en in vivo assays werden vervolgens uitgevoerd om te bereiken waarneming in het onderliggende mechanisme van NOL4L ovarium kanker .

We bevestigd dat de expressie van NOL4L werd verhoogd in tumor weefsels , in het bijzonder in peritoneale metastatische weefsels . Bovendien merkten we dat NOL4L geassocieerd was met de prognose van de meeste patiënten met eierstokkanker . Daaropvolgende we uitgevoerd CCK- Acht assays kolonievorming assays, migratie en invasie experimenten en wond therapeutische assays en geverifieerd dat NOL4L kan proliferatie en metastase bij eierstokkanker bevorderen kanker cellen.

cDNA from Rat Normal Tissue: Brain
C1434035	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Colon
C1434090	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Heart
C1434122	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Liver
C1434149	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Lung
C1434152	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Placenta
C1434200	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Rectum
C1434206	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Spleen
C1434246	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Stomach
C1434248	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Testis
C1434260	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Tumor Tissue: Kidney
C1235142	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Diabetic Tissue: Kidney
C1236142Dia	Biochain	40 reactions	EUR 668
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Matching Pair - cDNA from Human Primary Tumor and Normal Tissue: Kidney
C8235142-PP	Biochain	10 reactions x2	EUR 499
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Skeletal Muscle
C1434171	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Small Intestine
C1434226	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA from Rat Normal Tissue: Kidney
D1434142	Biochain	100 ug	EUR 282
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Rat Normal Tissue: Kidney
R1434142-50	Biochain	50 ug	EUR 152
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Adipose
C1334003	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Bladder
C1334010	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Brain
C1334035	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Colon
C1334090	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Heart
C1334122	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Liver
C1334149	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Lung
C1334152	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Placenta
C1334200	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Rectum
C1334206	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Spleen
C1334246	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Stomach
C1334248	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Testis
C1334260	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Bladder
C1734010	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Brain
C1734035	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Cecum
C1734089	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Esophagus
C1734106	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Heart
C1734122	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Liver
C1734149	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Lung
C1734152	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Trachea
C1734160	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Pancreas
C1734188	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Rectum
C1734206	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Stomach
C1734248	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Testis
C1734260	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Monkey (Cynomolgus) cDNA Normal Tissue: Liver
MC34-149	Alpha Diagnostics	10 rxn	EUR 415

Monkey (Cynomolgus) cDNA Normal Tissue: Pancreas
MC34-188	Alpha Diagnostics	10 rxn	EUR 415

Monkey (Cynomolgus) cDNA Normal Tissue: Spleen
MC34-246	Alpha Diagnostics	10 rxn	EUR 415

Rat Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells
9-80263	CHI Scientific	1 x 100 ml	Ask for price

cDNA from Plant Normal Tissue: cDNA from Plant: Arabidopsis
C1634310	Biochain	40 reactions	EUR 621
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Corn
C1634330	Biochain	40 reactions	EUR 621
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Orange
C1634340	Biochain	40 reactions	EUR 621
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Potato
C1634350	Biochain	40 reactions	EUR 621
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Rice
C1634360	Biochain	40 reactions	EUR 621
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Plant Normal Tissue: cDNA from Plant: Wheat
C1634390	Biochain	40 reactions	EUR 621
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Adipose
C1234003-10	Biochain	10 reactions	EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Adrenal
C1234004	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Bladder
C1234010	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain
C1234035	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Breast
C1234086	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Colon
C1234090	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Esophagus
C1234106	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Heart
C1234122	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Liver
C1234149	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Lung
C1234152	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Trachea
C1234160-10	Biochain	10 reactions	EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Ovary
C1234183	Biochain	40 reactions	EUR 939
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Pancreas
C1234188	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Placenta
C1234200	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Prostate
C1234201	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Rectum
C1234206	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Skin
C1234218	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Spleen
C1234246	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Stomach
C1234248	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Testis
C1234260	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Theca
C1234261-10	Biochain	10 reactions	EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Throat
C1234263-10	Biochain	10 reactions	EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Thymus
C1234264	Biochain	40 reactions	EUR 939
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Thyroid
C1234265	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Tongue
C1234267-10	Biochain	10 reactions	EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Tonsil
C1234268-10	Biochain	10 reactions	EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Uterus
C1234274	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Skeletal Muscle
C1334171	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Small Intestine
C1334226	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Adipose
C1534003	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Adipose
C1534003-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Adrenal
C1534004	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Adrenal
C1534004-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Appendix
C1534006	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Appendix
C1534006-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Bladder
C1534010	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Bladder
C1534010-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Brain
C1534035	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain
C1534035-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Brain:Cerebellum
C1534039-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Cecum
C1534089	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Cecum
C1534089-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Colon
C1534090	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Colon
C1534090-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Epididymis
C1534105	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Epididymis
C1534105-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Esophagus
C1534106	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Esophagus
C1534106-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Gallbladder
C1534118	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Gallbladder
C1534118-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Heart
C1534122	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Heart
C1534122-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Liver
C1534149	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Liver
C1534149-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Lung
C1534152	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Lung
C1534152-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Trachea
C1534160	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Trachea
C1534160-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Diaphragm
C1534169	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Diaphragm
C1534169-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Ovary
C1534183	Biochain	40 reactions	EUR 939
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Ovary
C1534183-Cy	Biochain	40 reactions	EUR 939
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Pancreas
C1534188	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Pancreas
C1534188-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Parathyroid
C1534189	Biochain	40 reactions	EUR 1051
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Parathyroid
C1534189-Cy	Biochain	40 reactions	EUR 1051
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Parotid
C1534190	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Parotid
C1534190-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Penis
C1534194	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Penis
C1534194-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Placenta
C1534200	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Placenta
C1534200-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Prostate
C1534201	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Prostate
C1534201-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Rectum
C1534206	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Rectum
C1534206-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Skin
C1534218	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Skin
C1534218-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Spleen
C1534246	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Spleen
C1534246-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Stomach
C1534248	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Stomach
C1534248-Cy	Biochain	40 reactions	EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Testis
C1534260	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Testis
C1534260-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Throat
C1534263	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Throat
C1534263-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Thymus
C1534264	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Thymus
C1534264-Cy	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Thyroid
C1534265	Biochain	40 reactions	EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Bovendien promootte NOL4L de ontwikkeling en uitzaaiing van tumoren in een naakte muizenpop. Mechanistisch hebben we aangetoond dat NOL4L genexpressie binnen de PI3K/AKT-route beïnvloedde. In totaal levert ons onderzoek genetisch en biochemisch bewijs dat NOL4L belangrijk is voor tumorontwikkeling en metastase in de meeste kankercellen van de eierstokken. Het kan dus een doel zijn voor antimetastatische remedie bij de meeste eierstokkankers.