Hepatocellulair carcinoom (HCC) is de eerste tumor van de lever en de vierde belangrijkste reden achter de meeste aan kanker gerelateerde overlijdens. Nog niet zo lang geleden wees een aantal onderzoeken op het antitumorpotentieel van antipsychotica. Quetiapine, een atypisch antipsychoticum, wordt sinds 1997 gebruikt voor de behandeling van schizofrenie, bipolaire stoornissen en depressieve stoornissen.
Desalniettemin is het nog steeds onduidelijk of quetiapine de ontwikkeling van HCC kan onderdrukken en of het onderliggende mechanisme ervan kan worden onderdrukt. Het is bewezen dat quetiapine in vitro apoptose induceert en de invasievaardigheid in HCC remt. Hier hebben we twee totaal verschillende HCC (Hep3B, SK-Hep1) dragende dieren vastgesteld om de therapie-effectiviteit van quetiapine te bepalen.
Tumorprogressie , signaaltransductie en reguliere weefselpathologie na behandeling met quetiapine zijn gevalideerd door respectievelijk schuifmaat, bioluminescentiebeeld, immunohistochemie ( IHC ) en hematoxyline- en eosinekleuring. Quetiapine onderdrukte de HCC-ontwikkeling op een dosisafhankelijke methode.
Extracellulaire signaalgereguleerde kinasen (ERK’s) en door kernfactor-KB (NF-KB) gemedieerde stroomafwaartse eiwitten, vergelijkbaar met myeloïde leukemieceldifferentiatie-eiwit (MCL-1), mobiel FLICE-remmend eiwit (C-FLIP), X-gekoppelde remmer van apoptose-eiwit (XIAP), Cyclin-D1, matrix metallopeptidase 9 (MMP-9) , vasculaire endotheliale progressiefactor-A (VEGF-A) en indoleamine 2,3-dioxygenase (IDO) die betrekking hadden op proliferatie, overleving, angiogenese, invasie en antitumorimmuniteit zijn allemaal verminderd door quetiapine.
Daarnaast zijn extrinsieke/intrinsieke caspase-afhankelijke en caspase-onafhankelijke routes, samen met gesplitste caspase-3, -8 en – 9 verhoogd door quetiapine. Kortom, de tumor remmen die uitkomsten van quetiapine lid kon met ERK en NFKB inactivatie.
Afwijkende expressie van MYD88 door middel van RNA-controlerende CNOT4 en EXOSC3 in colonmucosa heeft invloed op de technologie van de meeste kankers in de dikke darm
In 2020, de wereldwijde incidentie en mortaliteit van colorectale kanker (CRC) zijn derde tweede, respectievelijk. Omdat de vijf jaar te overleven prijs is laag wanneer CRC wordt geïdentificeerd in een ingewikkeld stadium, een betrouwbare techniek te voorspellen CRC gevoeligheid is van essentieel belang voor het stoppen van het ontstaan en de groei en het verbeteren van de prognose van de CRC.
Vervolgens hebben we ons geconcentreerd op het conventionele colonmucosa om veranderingen in genexpressie te onderzoeken die daaropvolgende genetische veranderingen zullen induceren die kwaadaardige transformatie induceren. Volledige genexpressie profilering in de normale mucosa grenzend aan colon kanker (CC) vergeleken met weefsel van noncolon kanker (NCC) patiënten werd uitgevoerd .
PCR-arrays en qRT-PCR onthulden dat de expressie van 5 genen die betrokken zijn bij de immuunrespons, samen met MYD88, verhoogd was in het reguliere slijmvlies van CC- patiënten . De expressie varieert van MyD88 zijn opvallend verhoogd pre kanker ous normale mucosa specimens, waarvoor geen somatische mutaties herbergden, zoals aangetoond door immunohistochemie ( IHC ).
Microarray evaluatie herkende twee nieuwe RNA-moleculen regelen, EXOSC3 en CNOT4, die zijn aanzienlijk opwaarts gereguleerd binnen het normale slijmvlies van CC patiënten en zijn duidelijk zichtbaar in de kernen.
Gedwongen expressie van EXOSC3 en CNOT4 in menselijke colonepitheelcellen verhoogde de expressie van IFNGR1, MYD88, NFκBIA en STAT3 en activeerde ERK1/2 en JNK in 293T-cellen. Genomen collectief , deze uitkomsten raadsman dat binnen de geïnfecteerde slijmvlies, EXOSC3- en CNOT4-gemedieerde RNA stabilisatie, samen met die van MyD88, kon verrekenen het geval van de meeste vormen van kanker en kan functioneren een mogelijke voorspellende marker en revolutionaire therapie voor het beheer van de meeste vormen van kanker groei .
Fluorescerende multiplex-immunohistochemie in combinatie met verschillende ultramoderne methoden om de tumor- immuunmicro-omgeving systematisch te karakteriseren
Onze het verhogen van informatie van de interacties tussen tumor cellen en hun micro-omgeving heeft geholpen om een revolutie meeste vormen van kanker remedies , samen met de nieuwere groei van immuuntherapie. Immuuncellen zijn een essentieel onderdeel van de micro-omgeving van de tumor die de ontwikkeling en therapieresponsen beïnvloeden, met name op de gloednieuwe immunotherapieën.
Technologische vooruitgang die helpen om de complexiteit te ontcijferen en de verscheidenheid van de tumor immuun micro-omgeving (TIME) zijn meer en meer gebruikt in translationeel onderzoek en biomarker onderzoek . Huidige methoden die TIME- analyse vergemakkelijken , omvatten circulerende cytometrie, op multiplex gebaseerde immunoassays, chromogene immunohistochemie ( IHC ), fluorescerende multiplex IHC , immunofluorescentie en ruimtelijke transcriptomics.
Deze tekst geeft een samenvatting van onze consultant informatie , bespreekt het apparaat van elke strategie om het onderzoek van de tijd, samen met hun voordelen en uitdagingen, en adviezen van het potentieel wetenschappelijke doeleinden . Move cytometry en chromogene en fluorescerende multiplex IHC zijn gebruikt om het immuunsysteem profiel een HER2 + borstkanker meeste vormen van kanker , ter illustratie van een aantal factoren .
Ruimtelijke transcriptoom evaluatie van een luminale B borst tumor aangetoond dat essentiële verder perceptie kan worden opgedaan met deze nieuwe methode . Tenslotte , indien van multiplex paneel om te bepalen prolifererende B-cellen, Tfh en Tfr cellen op de identieke weefsel gedeelte toont de co-localisatie in tertiaire lymfoïde gebouwen .
Incidentie van schildkliercarcinomen in een langdurig retrospectief onderzoek van 526 autopsies
Schildklier meeste vormen van kanker is goed voor 1% van alle maligniteiten, en veranderen in meer en meer verspreid over de hele wereld. De literatuur vermeldt een prevalentie van ~50% van de schildklierknobbeltjes die werden gedetecteerd tijdens autopsies bij onderwerpen met onbekende schildklierpathologie.
Een langdurig retrospectief onderzoek van 526 postmortale gevallen werd uitgevoerd om de prevalentie van schildkliercarcinoom te bepalen , onder de talrijke vormen van schildklierknobbeltjes die overigens worden herkend . Tissue monsters zijn genomen van schildklier knobbeltjes, voor onderzoek naar de aanwezigheid van schildkliercarcinoom, samen met hun macroscopische en microscopische opties via histopathologie en immunohistochemie ( IHC ) strategieën .
Histopathologische analyse van maligniteit was aanwezig in 51 gevallen van geanalyseerde schildkliermonsters. Systematisch gedetailleerd onderzoek toonde aan {dat een} schildklier, schijnbaar regelmatig bij macroscopisch onderzoek, de website zal zijn van pathologische manifestaties, die typisch carcinomateuze bevindingen presenteren.
Onder schildkliercarcinomen was de allerbeste frequentie die van papillaire microcarcinomen, die een langdurige evolutie hebben en trouwens worden gedetecteerd tijdens autopsies. Papillair microcarcinoom is een bijzonder wijdverbreide incidentele ontdekking en de overgrote meerderheid van die tumoren volgt een goedaardig verloop. Bovendien , is het gevolg van dit feit essentieel maken landelijke screening aanvragen voor de vroegtijdige detectie van schildkliercarcinoom.
NOL4L, een nieuw nucleair eiwit, bevordert celproliferatie en metastase door de PI3K/AKT-route bij de meeste eierstokkankers te verbeteren
Nucleolair eiwit 4-achtig (NOL4L) werd voor het eerst herkend bij acute myeloïde leukemie. Daarna werd het gecontroleerd te worden betrokken in cel ontwikkeling in neuroblastoom. Desalniettemin worden de praktische positie van NOL4L in tumorproliferatie en metastase en de onderliggende moleculaire mechanismen meestal niet volledig begrepen.
Immunohistochemie ( IHC ) testen zijn uitgevoerd in weefsels van aangetaste personen om NOL4L-expressieprofielen te onthullen . Dan hebben we neergehaald NOL4L twee ovariële kanker cel stammen (SKOV3-IP1 en He) en cellen gebaseerde in vitro en in vivo assays werden vervolgens uitgevoerd om te bereiken waarneming in het onderliggende mechanisme van NOL4L ovarium kanker .
We bevestigd dat de expressie van NOL4L werd verhoogd in tumor weefsels , in het bijzonder in peritoneale metastatische weefsels . Bovendien merkten we dat NOL4L geassocieerd was met de prognose van de meeste patiënten met eierstokkanker . Daaropvolgende we uitgevoerd CCK- Acht assays kolonievorming assays, migratie en invasie experimenten en wond therapeutische assays en geverifieerd dat NOL4L kan proliferatie en metastase bij eierstokkanker bevorderen kanker cellen.
Genomic DNA - Rat Normal Tissue: Kidney |
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| D1434142 | Biochain | 100 ug | EUR 286 |
Rat normal kidney tissue array |
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| TR071a | TissueArray | each | EUR 48 |
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Description: Rat normal kidney tissue array, 6 cases/24 cores, replacing TR071 |
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Normal kidney and normal adjacent kidney tissue array |
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| KDN241a | TissueArray | each | EUR 138 |
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Description: Normal kidney and normal adjacent kidney tissue array, 24 cases/ 24 cores |
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Kidney cancer tissue array with normal Kidney tissue |
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| KD2082a | TissueArray | each | EUR 474 |
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Description: Kidney cancer tissue array with normal Kidney tissue, including TNM and pathology grade, 96 cases/192 cores, replacing KD2082 |
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Kidney Tissue Slide (Normal) |
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| 10-401-10um | ProSci | 10 um | EUR 241.8 |
Kidney Tissue Slide (Normal) |
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| 10-401-4um | ProSci | 4 um | EUR 216.6 |
Normal kidney tissue array |
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| KD803 | TissueArray | each | EUR 354 |
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Description: Normal kidney tissue array, replacing BN07012, 80 cases/80 cores |
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Normal kidney tissue array |
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| KDN242 | TissueArray | each | EUR 72 |
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Description: Normal kidney tissue array, 24 cases/24 cores |
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Kidney Tissue Lysate (Normal) |
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| 1706-02 | ProSci | 0.1 mg | EUR 260.7 |
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Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol. |
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Kidney Tissue Lysate (Normal) |
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| 1706-03 | ProSci | 0.1 mg | EUR 260.7 |
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Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol. |
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Kidney Tissue Lysate (Normal) |
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| 1706-04 | ProSci | 0.1 mg | EUR 260.7 |
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Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol. |
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Kidney Tissue Lysate (Normal) |
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| 1706-05 | ProSci | 0.1 mg | EUR 260.7 |
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Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol. |
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Kidney cancer tissue array with adjacent normal kidney tissue |
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| BC07015b | TissueArray | each | EUR 168 |
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Description: Kidney cancer tissue array with adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 72 cases/72 cores, replacing BC07015a |
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Total RNA - Mouse Normal Tissue: Kidney |
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| R1334142-50 | Biochain | 50 ug | EUR 130 |
Genomic DNA - Mouse Normal Tissue: Kidney |
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| D1334142 | Biochain | 100 ug | EUR 286 |
Total Protein - Mouse Normal Tissue: Kidney |
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| P1334142 | Biochain | 1 mg | EUR 188 |
Kidney cancer tissue array with matched adjacent normal kidney tissue |
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| KD901a | TissueArray | each | EUR 258 |
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Description: Kidney cancer tissue array with matched adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 40 cases/90 cores, replacing KD901 |
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Kidney tumour with normal tissue array |
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| KD2001 | TissueArray | each | EUR 474 |
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Description: Kidney tumour with normal tissue array, including Clear cell carcinoma (CCRCC), Sarcomatoid carcinoma, Papillary renal cell carcinoma (PRCC), Chromopobe carcinoma(crcc), Invasive low grade urothelial carcinoma, with Isup Grade, TNM/Stage (AJCC 8th edition), 100 cases/200 cores (core size 1.0mm),replacing BC07114 |
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Total RNA - Human Adult Normal Tissue: Kidney |
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| R1234142-50 | Biochain | 50 ug | EUR 170 |
cDNA - Rat Normal Tissue: Lung |
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| C1434152 | Biochain | 40 reactions | EUR 385 |
cDNA - Rat Normal Tissue: Brain |
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| C1434035 | Biochain | 40 reactions | EUR 385 |
cDNA - Rat Normal Tissue: Colon |
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| C1434090 | Biochain | 40 reactions | EUR 578 |
cDNA - Rat Normal Tissue: Heart |
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| C1434122 | Biochain | 40 reactions | EUR 385 |
cDNA - Rat Normal Tissue: Liver |
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| C1434149 | Biochain | 40 reactions | EUR 385 |
Kidney cancer tissue array with normal tissues |
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| KD2083 | TissueArray | each | EUR 474 |
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Description: Kidney cancer tissue array with normal tissues, with stage and grade info, 69 cases/208 cores |
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Kidney cancer tissue array with normal tissues |
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| KD721 | TissueArray | each | EUR 168 |
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Description: Kidney cancer tissue array with normal tissues, 24 cases/72 cores |
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cDNA - Rat Normal Tissue: Rectum |
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| C1434206 | Biochain | 40 reactions | EUR 578 |
cDNA - Rat Normal Tissue: Spleen |
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| C1434246 | Biochain | 40 reactions | EUR 385 |
cDNA - Rat Normal Tissue: Testis |
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| C1434260 | Biochain | 40 reactions | EUR 385 |
Mouse Normal Tissue: Kidney Whole Cell Lysate |
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| MNK-100 | Alpha Diagnostics | 1 mg | EUR 628.8 |
Mouse Normal Tissue: Kidney Whole Cell Lysate |
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| MNK-50 | Alpha Diagnostics | 50 ug | EUR 196.8 |
Total RNA - Monkey (Rhesus) Normal Tissue: Kidney |
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| R1534142-50 | Biochain | 50 ug | EUR 191 |
cDNA - Rat Normal Tissue: Adipose |
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| C1434003 | Biochain | 40 reactions | EUR 578 |
cDNA - Rat Normal Tissue: Bladder |
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| C1434010 | Biochain | 40 reactions | EUR 385 |
cDNA - Rat Normal Tissue: Stomach |
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| C1434248 | Biochain | 40 reactions | EUR 385 |
cDNA - Rat Normal Tissue: Placenta |
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| C1434200 | Biochain | 40 reactions | EUR 578 |
Kidney tumor tissue array with normal tissue as control |
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| KD961 | TissueArray | each | EUR 258 |
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Description: Kidney tumor tissue array with normal tissue as control, including TNM, clinical stage and pathology grade, 48 cases/96 cores |
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Total Protein - Human Adult Normal Tissue: Kidney |
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| P1234142 | Biochain | 1 mg | EUR 188 |
Kidney cancer tissue array with normal tissue as control |
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| KD962 | TissueArray | each | EUR 258 |
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Description: Kidney cancer tissue array with normal tissue as control, including TNM, clinical stage and pathology grade, 48 cases/96 cores |
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Rat Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells |
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| 9-80263 | CHI Scientific | 1 x 100 ml | Ask for price |
Total RNA - Monkey (Cynomolgus) Normal Tissue: Kidney |
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| R1534142-Cy | Biochain | 50 ug | EUR 191 |
Membrane Protein - Human Adult Normal Tissue: Kidney |
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| P3234142 | Biochain | 0.1 mg | EUR 270 |
Adjacent normal kidney tissue and cancer tissue array |
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| BN07011b | TissueArray | each | EUR 203 |
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Description: Adjacent normal kidney tissue and cancer tissue array, including pathology grade, TNM and clinical stage, 20 cases/54 cores, replacing BN07011 |
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Kidney cancer (grade I) tissue array with matched adjacent normal kidney tissue |
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| KD701a | TissueArray | each | EUR 234 |
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Description: Kidney cancer (grade I) tissue array with matched adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 35 cases/70 cores, replacing KD701 |
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cDNA - Human Tumor Tissue: Kidney |
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| C1235142 | Biochain | 40 reactions | EUR 578 |
Kidney cancer tissue array with matched adjacent normal tissue |
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| KD321a | TissueArray | each | EUR 198 |
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Description: Kidney cancer tissue array with matched adjacent normal tissue, including TNM, clinical stage and pathology ISUP grade, 16 cases/32 cores, replacing KD321 |
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Kidney cancer with matched adjacent normal kidney tissue array |
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| KD603 | TissueArray | each | EUR 204 |
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Description: Kidney cancer with matched adjacent normal kidney tissue array, containing metastatic clear cell carcinoma, including pathology grade, TNM and clinical stage (reference AJCC 8th version), 33 cases/61 cores |
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Kidney cancer tissue array with matched normal adjacent or caner adjacent kidney tissue |
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| Kid-060Sur01 | TissueArray | each | EUR 954 |
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Description: Kidney cancer tissue array with matched normal adjacent or caner adjacent kidney tissue, including TNM, ISUP grade and survival data, 30 cases/60 cores |
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cDNA - Rat Normal Tissue: Skeletal Muscle |
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| C1434171 | Biochain | 40 reactions | EUR 385 |
cDNA - Rat Normal Tissue: Small Intestine |
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| C1434226 | Biochain | 40 reactions | EUR 578 |
Monkey (Cyno.) Normal Kidney Whole tissue lysate |
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| MCL-1190 | Alpha Diagnostics | 1 mg | EUR 628.8 |
Human Adult Kidney (Normal) Whole tissue lysate |
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| HAL-1305 | Alpha Diagnostics | 1 mg | EUR 628.8 |
Monkey (Rhesus) Normal Kidney Whole tissue lysate |
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| MRL-1301 | Alpha Diagnostics | 1 mg | EUR 628.8 |
Frozen Tissue Section - Human Adult Normal: Kidney |
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| T1234142 | Biochain | 5 slides | EUR 343 |
Kidney Tumor Tissue Array - 12 cases of kidney cancer paired with adjacent normal tissues |
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| Z7020053 | Biochain | 5 slides | EUR 1125.6 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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Human Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells |
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| 9-80075 | CHI Scientific | 1 x 100 ml | Ask for price |
Mouse Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells |
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| 9-80171 | CHI Scientific | 1 x 100 ml | Ask for price |
Paraffin Tissue Section - Human Adult Normal: Kidney |
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| T2234142 | Biochain | 5 slides | EUR 185 |
cDNA - Plant Normal Tissue: cDNA - Plant: Corn |
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| C1634330 | Biochain | 40 reactions | EUR 674 |
cDNA - Plant Normal Tissue: cDNA - Plant: Rice |
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| C1634360 | Biochain | 40 reactions | EUR 674 |
Multiple Kidney cancer tissue array with normal tissue control from autopsy |
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| KD483 | TissueArray | each | EUR 168 |
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Description: Multiple Kidney cancer tissue array with normal tissue control from autopsy, 48 cases/48 cores, with stage and grade data |
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cDNA - Plant Normal Tissue: cDNA - Plant: Wheat |
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| C1634390 | Biochain | 40 reactions | EUR 674 |
cDNA - Human Diabetic Diseased Tissue: Kidney |
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| C1236142Dia | Biochain | 40 reactions | EUR 729 |
cDNA - Plant Normal Tissue: cDNA - Plant: Orange |
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| C1634340 | Biochain | 40 reactions | EUR 674 |
cDNA - Plant Normal Tissue: cDNA - Plant: Potato |
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| C1634350 | Biochain | 40 reactions | EUR 674 |
Matched Pair - DNA - Human Primary Tumor and Normal Tissue: Kidney |
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| D8235142-PP-10 | Biochain | 2x10 ug | EUR 416 |
cDNA - Dog Normal Tissue: Lung |
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| C1734152 | Biochain | 40 reactions | EUR 385 |
Total RNA - Human Adult Normal Tissue 5 Donor Pool: Kidney |
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| R1234142-P | Biochain | 50 ug | EUR 370 |
cDNA - Dog Normal Tissue: Brain |
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| C1734035 | Biochain | 40 reactions | EUR 385 |
cDNA - Dog Normal Tissue: Cecum |
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| C1734089 | Biochain | 40 reactions | EUR 385 |
cDNA - Dog Normal Tissue: Heart |
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| C1734122 | Biochain | 40 reactions | EUR 385 |
cDNA - Dog Normal Tissue: Liver |
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| C1734149 | Biochain | 40 reactions | EUR 385 |
cDNA - Dog Normal Tissue: Rectum |
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| C1734206 | Biochain | 40 reactions | EUR 385 |
cDNA - Dog Normal Tissue: Testis |
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| C1734260 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Lung |
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| C1334152 | Biochain | 40 reactions | EUR 385 |
Rat Kidney Tissue Preparation Buffer 6: Normal Renal Firbroblasts |
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| 9-80267 | CHI Scientific | 1 x 100 ml | Ask for price |
cDNA - Dog Normal Tissue: Bladder |
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| C1734010 | Biochain | 40 reactions | EUR 385 |
cDNA - Dog Normal Tissue: Trachea |
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| C1734160 | Biochain | 40 reactions | EUR 385 |
cDNA - Dog Normal Tissue: Stomach |
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| C1734248 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Brain |
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| C1334035 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Colon |
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| C1334090 | Biochain | 40 reactions | EUR 578 |
cDNA - Mouse Normal Tissue: Heart |
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| C1334122 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Liver |
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| C1334149 | Biochain | 40 reactions | EUR 385 |
Rat Normal Kidney tissue (single section per slide) (5 slides/pack) |
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| RaFPT007 | TissueArray | 5 slides | EUR 150 |
cDNA - Plant Normal Tissue: cDNA - Plant: Arabidopsis |
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| C1634310 | Biochain | 40 reactions | EUR 674 |
cDNA - Dog Normal Tissue: Pancreas |
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| C1734188 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Rectum |
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| C1334206 | Biochain | 40 reactions | EUR 578 |
cDNA - Mouse Normal Tissue: Spleen |
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| C1334246 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Testis |
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| C1334260 | Biochain | 40 reactions | EUR 385 |
cDNA - Plant Normal Tissue: cDNA - Plant: Soy bean |
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| C1634370 | Biochain | 40 reactions | EUR 674 |
Genomic DNA - Human Adult Normal Tissue: Kidney, from a single donor |
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| D1234142 | Biochain | 100 ug | EUR 286 |
High density tissue array (70 cases/208 cores) of kidney cancer and normal tissue |
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| KD208 | TissueArray | each | EUR 546 |
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Description: High density tissue array (70 cases/208 cores) of kidney cancer and normal tissue |
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cDNA - Dog Normal Tissue: Esophagus |
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| C1734106 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Adipose |
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| C1334003 | Biochain | 40 reactions | EUR 578 |
cDNA - Mouse Normal Tissue: Bladder |
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| C1334010 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Stomach |
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| C1334248 | Biochain | 40 reactions | EUR 385 |
cDNA - Mouse Normal Tissue: Placenta |
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| C1334200 | Biochain | 40 reactions | EUR 578 |
Matched Pair - Total RNA - Human Primary Tumor and Normal Tissue: Kidney |
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| R8235142-PP-10 | Biochain | 2x10 ug | EUR 463 |
Mouse Kidney Tissue Preparation Buffer 3: Normal Podocytes |
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| 9-80172 | CHI Scientific | 1 x 100 ml | Ask for price |
Multiple Kidney cancer test tissue array with unmatched normal adjacent tissue |
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| KD242 | TissueArray | each | EUR 48 |
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Description: Multiple Kidney cancer test tissue array with unmatched normal adjacent tissue, 10 cases/24 cores |
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Kidney cancer with matched cancer adjacent normal tissue test array |
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| KD241 | TissueArray | each | EUR 48 |
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Description: Kidney cancer with matched cancer adjacent normal tissue test array, including TNM and clinical stage, 6 cases/24 cores |
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Kidney cancer with matched cancer adjacent normal tissue test array |
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| KD241a | TissueArray | each | EUR 66 |
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Description: Kidney cancer with matched cancer adjacent normal tissue test array, including TNM and clinical stage, 6 cases/24 cores, replacing KD241 |
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cDNA - Human Adult Normal Tissue: Lung |
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| C1234152 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Skin |
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| C1234218 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Brain |
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| C1234035 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Colon |
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| C1234090 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Heart |
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| C1234122 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Liver |
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| C1234149 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Ovary |
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| C1234183 | Biochain | 40 reactions | EUR 1049 |
cDNA - Human Adult Normal Tissue: Theca |
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| C1234261-10 | Biochain | 10 reactions | EUR 215 |
Matched Pair - Total Protein - Human Primary Tumor and Normal Tissue (PP): Kidney |
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| P8235142-PP | Biochain | 0.2 mg x2 | EUR 663 |
Rat Kidney Tissue Preparation Buffer 1: Normal Glomerular Endothelial Cells |
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| 9-80262 | CHI Scientific | 1 x 100 ml | Ask for price |
cDNA - Monkey (Rhesus) Normal Tissue: Lung |
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| C1534152 | Biochain | 40 reactions | EUR 385 |
cDNA - Monkey (Rhesus) Normal Tissue: Skin |
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| C1534218 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Breast |
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| C1234086 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Rectum |
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| C1234206 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Spleen |
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| C1234246 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Testis |
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| C1234260 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Throat |
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| C1234263-10 | Biochain | 10 reactions | EUR 215 |
cDNA - Human Adult Normal Tissue: Thymus |
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| C1234264 | Biochain | 40 reactions | EUR 1049 |
cDNA - Human Adult Normal Tissue: Tongue |
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| C1234267-10 | Biochain | 10 reactions | EUR 215 |
cDNA - Human Adult Normal Tissue: Tonsil |
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| C1234268-10 | Biochain | 10 reactions | EUR 215 |
cDNA - Human Adult Normal Tissue: Uterus |
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| C1234274 | Biochain | 40 reactions | EUR 385 |
Human Kidney Tissue Preparation Buffer 6: Normal Renal Podocytes |
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| 9-80079 | CHI Scientific | 1 x 100 ml | Ask for price |
cDNA - Monkey (Rhesus) Normal Tissue: Brain |
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| C1534035 | Biochain | 40 reactions | EUR 385 |
cDNA - Monkey (Rhesus) Normal Tissue: Cecum |
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| C1534089 | Biochain | 40 reactions | EUR 578 |
cDNA - Monkey (Rhesus) Normal Tissue: Colon |
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| C1534090 | Biochain | 40 reactions | EUR 385 |
cDNA - Monkey (Rhesus) Normal Tissue: Heart |
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| C1534122 | Biochain | 40 reactions | EUR 385 |
cDNA - Monkey (Rhesus) Normal Tissue: Liver |
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| C1534149 | Biochain | 40 reactions | EUR 385 |
cDNA - Monkey (Rhesus) Normal Tissue: Ovary |
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| C1534183 | Biochain | 40 reactions | EUR 1049 |
cDNA - Monkey (Rhesus) Normal Tissue: Penis |
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| C1534194 | Biochain | 40 reactions | EUR 578 |
cDNA - Dog Normal Tissue: Skeletal Muscle |
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| C1734171 | Biochain | 40 reactions | EUR 385 |
cDNA - Dog Normal Tissue: Small Intestine |
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| C1734226 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Adipose |
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| C1234003-10 | Biochain | 10 reactions | EUR 215 |
cDNA - Human Adult Normal Tissue: Adrenal |
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| C1234004 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Bladder |
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| C1234010 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Trachea |
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| C1234160-10 | Biochain | 10 reactions | EUR 215 |
cDNA - Human Adult Normal Tissue: Stomach |
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| C1234248 | Biochain | 40 reactions | EUR 385 |
cDNA - Human Adult Normal Tissue: Thyroid |
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| C1234265 | Biochain | 40 reactions | EUR 385 |
cDNA - Monkey (Rhesus) Normal Tissue: Rectum |
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| C1534206 | Biochain | 40 reactions | EUR 385 |
Bovendien promootte NOL4L de ontwikkeling en uitzaaiing van tumoren in een naakte muizenpop. Mechanistisch hebben we aangetoond dat NOL4L genexpressie binnen de PI3K/AKT-route beïnvloedde. In totaal levert ons onderzoek genetisch en biochemisch bewijs dat NOL4L belangrijk is voor tumorontwikkeling en metastase in de meeste kankercellen van de eierstokken. Het kan dus een doel zijn voor antimetastatische remedie bij de meeste eierstokkankers.
