Hepatocellulair carcinoom (HCC) is de eerste tumor van de lever en de vierde belangrijkste reden achter de meeste aan kanker gerelateerde overlijdens. Nog niet zo lang geleden wees een aantal onderzoeken op het antitumorpotentieel van antipsychotica. Quetiapine, een atypisch antipsychoticum, wordt sinds 1997 gebruikt voor de behandeling van schizofrenie, bipolaire stoornissen en depressieve stoornissen.
Desalniettemin is het nog steeds onduidelijk of quetiapine de ontwikkeling van HCC kan onderdrukken en of het onderliggende mechanisme ervan kan worden onderdrukt. Het is bewezen dat quetiapine in vitro apoptose induceert en de invasievaardigheid in HCC remt. Hier hebben we twee totaal verschillende HCC (Hep3B, SK-Hep1) dragende dieren vastgesteld om de therapie-effectiviteit van quetiapine te bepalen.
Tumorprogressie , signaaltransductie en reguliere weefselpathologie na behandeling met quetiapine zijn gevalideerd door respectievelijk schuifmaat, bioluminescentiebeeld, immunohistochemie ( IHC ) en hematoxyline- en eosinekleuring. Quetiapine onderdrukte de HCC-ontwikkeling op een dosisafhankelijke methode.
Extracellulaire signaalgereguleerde kinasen (ERK’s) en door kernfactor-KB (NF-KB) gemedieerde stroomafwaartse eiwitten, vergelijkbaar met myeloïde leukemieceldifferentiatie-eiwit (MCL-1), mobiel FLICE-remmend eiwit (C-FLIP), X-gekoppelde remmer van apoptose-eiwit (XIAP), Cyclin-D1, matrix metallopeptidase 9 (MMP-9) , vasculaire endotheliale progressiefactor-A (VEGF-A) en indoleamine 2,3-dioxygenase (IDO) die betrekking hadden op proliferatie, overleving, angiogenese, invasie en antitumorimmuniteit zijn allemaal verminderd door quetiapine.
Daarnaast zijn extrinsieke/intrinsieke caspase-afhankelijke en caspase-onafhankelijke routes, samen met gesplitste caspase-3, -8 en – 9 verhoogd door quetiapine. Kortom, de tumor remmen die uitkomsten van quetiapine lid kon met ERK en NFKB inactivatie.
Afwijkende expressie van MYD88 door middel van RNA-controlerende CNOT4 en EXOSC3 in colonmucosa heeft invloed op de technologie van de meeste kankers in de dikke darm
In 2020, de wereldwijde incidentie en mortaliteit van colorectale kanker (CRC) zijn derde tweede, respectievelijk. Omdat de vijf jaar te overleven prijs is laag wanneer CRC wordt geïdentificeerd in een ingewikkeld stadium, een betrouwbare techniek te voorspellen CRC gevoeligheid is van essentieel belang voor het stoppen van het ontstaan en de groei en het verbeteren van de prognose van de CRC.
Vervolgens hebben we ons geconcentreerd op het conventionele colonmucosa om veranderingen in genexpressie te onderzoeken die daaropvolgende genetische veranderingen zullen induceren die kwaadaardige transformatie induceren. Volledige genexpressie profilering in de normale mucosa grenzend aan colon kanker (CC) vergeleken met weefsel van noncolon kanker (NCC) patiënten werd uitgevoerd .
PCR-arrays en qRT-PCR onthulden dat de expressie van 5 genen die betrokken zijn bij de immuunrespons, samen met MYD88, verhoogd was in het reguliere slijmvlies van CC- patiënten . De expressie varieert van MyD88 zijn opvallend verhoogd pre kanker ous normale mucosa specimens, waarvoor geen somatische mutaties herbergden, zoals aangetoond door immunohistochemie ( IHC ).
Microarray evaluatie herkende twee nieuwe RNA-moleculen regelen, EXOSC3 en CNOT4, die zijn aanzienlijk opwaarts gereguleerd binnen het normale slijmvlies van CC patiënten en zijn duidelijk zichtbaar in de kernen.
Gedwongen expressie van EXOSC3 en CNOT4 in menselijke colonepitheelcellen verhoogde de expressie van IFNGR1, MYD88, NFκBIA en STAT3 en activeerde ERK1/2 en JNK in 293T-cellen. Genomen collectief , deze uitkomsten raadsman dat binnen de geïnfecteerde slijmvlies, EXOSC3- en CNOT4-gemedieerde RNA stabilisatie, samen met die van MyD88, kon verrekenen het geval van de meeste vormen van kanker en kan functioneren een mogelijke voorspellende marker en revolutionaire therapie voor het beheer van de meeste vormen van kanker groei .
Fluorescerende multiplex-immunohistochemie in combinatie met verschillende ultramoderne methoden om de tumor- immuunmicro-omgeving systematisch te karakteriseren
Onze het verhogen van informatie van de interacties tussen tumor cellen en hun micro-omgeving heeft geholpen om een revolutie meeste vormen van kanker remedies , samen met de nieuwere groei van immuuntherapie. Immuuncellen zijn een essentieel onderdeel van de micro-omgeving van de tumor die de ontwikkeling en therapieresponsen beïnvloeden, met name op de gloednieuwe immunotherapieën.
Technologische vooruitgang die helpen om de complexiteit te ontcijferen en de verscheidenheid van de tumor immuun micro-omgeving (TIME) zijn meer en meer gebruikt in translationeel onderzoek en biomarker onderzoek . Huidige methoden die TIME- analyse vergemakkelijken , omvatten circulerende cytometrie, op multiplex gebaseerde immunoassays, chromogene immunohistochemie ( IHC ), fluorescerende multiplex IHC , immunofluorescentie en ruimtelijke transcriptomics.
Deze tekst geeft een samenvatting van onze consultant informatie , bespreekt het apparaat van elke strategie om het onderzoek van de tijd, samen met hun voordelen en uitdagingen, en adviezen van het potentieel wetenschappelijke doeleinden . Move cytometry en chromogene en fluorescerende multiplex IHC zijn gebruikt om het immuunsysteem profiel een HER2 + borstkanker meeste vormen van kanker , ter illustratie van een aantal factoren .
Ruimtelijke transcriptoom evaluatie van een luminale B borst tumor aangetoond dat essentiële verder perceptie kan worden opgedaan met deze nieuwe methode . Tenslotte , indien van multiplex paneel om te bepalen prolifererende B-cellen, Tfh en Tfr cellen op de identieke weefsel gedeelte toont de co-localisatie in tertiaire lymfoïde gebouwen .
Incidentie van schildkliercarcinomen in een langdurig retrospectief onderzoek van 526 autopsies
Schildklier meeste vormen van kanker is goed voor 1% van alle maligniteiten, en veranderen in meer en meer verspreid over de hele wereld. De literatuur vermeldt een prevalentie van ~50% van de schildklierknobbeltjes die werden gedetecteerd tijdens autopsies bij onderwerpen met onbekende schildklierpathologie.
Een langdurig retrospectief onderzoek van 526 postmortale gevallen werd uitgevoerd om de prevalentie van schildkliercarcinoom te bepalen , onder de talrijke vormen van schildklierknobbeltjes die overigens worden herkend . Tissue monsters zijn genomen van schildklier knobbeltjes, voor onderzoek naar de aanwezigheid van schildkliercarcinoom, samen met hun macroscopische en microscopische opties via histopathologie en immunohistochemie ( IHC ) strategieën .
Histopathologische analyse van maligniteit was aanwezig in 51 gevallen van geanalyseerde schildkliermonsters. Systematisch gedetailleerd onderzoek toonde aan {dat een} schildklier, schijnbaar regelmatig bij macroscopisch onderzoek, de website zal zijn van pathologische manifestaties, die typisch carcinomateuze bevindingen presenteren.
Onder schildkliercarcinomen was de allerbeste frequentie die van papillaire microcarcinomen, die een langdurige evolutie hebben en trouwens worden gedetecteerd tijdens autopsies. Papillair microcarcinoom is een bijzonder wijdverbreide incidentele ontdekking en de overgrote meerderheid van die tumoren volgt een goedaardig verloop. Bovendien , is het gevolg van dit feit essentieel maken landelijke screening aanvragen voor de vroegtijdige detectie van schildkliercarcinoom.
NOL4L, een nieuw nucleair eiwit, bevordert celproliferatie en metastase door de PI3K/AKT-route bij de meeste eierstokkankers te verbeteren
Nucleolair eiwit 4-achtig (NOL4L) werd voor het eerst herkend bij acute myeloïde leukemie. Daarna werd het gecontroleerd te worden betrokken in cel ontwikkeling in neuroblastoom. Desalniettemin worden de praktische positie van NOL4L in tumorproliferatie en metastase en de onderliggende moleculaire mechanismen meestal niet volledig begrepen.
Immunohistochemie ( IHC ) testen zijn uitgevoerd in weefsels van aangetaste personen om NOL4L-expressieprofielen te onthullen . Dan hebben we neergehaald NOL4L twee ovariële kanker cel stammen (SKOV3-IP1 en He) en cellen gebaseerde in vitro en in vivo assays werden vervolgens uitgevoerd om te bereiken waarneming in het onderliggende mechanisme van NOL4L ovarium kanker .
We bevestigd dat de expressie van NOL4L werd verhoogd in tumor weefsels , in het bijzonder in peritoneale metastatische weefsels . Bovendien merkten we dat NOL4L geassocieerd was met de prognose van de meeste patiënten met eierstokkanker . Daaropvolgende we uitgevoerd CCK- Acht assays kolonievorming assays, migratie en invasie experimenten en wond therapeutische assays en geverifieerd dat NOL4L kan proliferatie en metastase bij eierstokkanker bevorderen kanker cellen.
Kidney Tissue Slide (Normal) |
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| 10-401-4um | ProSci | 4 um | EUR 216.6 |
Kidney Tissue Lysate (Normal) |
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| 1706-02 | ProSci | 0.1 mg | EUR 260.7 |
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Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol. |
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Kidney Tissue Lysate (Normal) |
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| 1706-03 | ProSci | 0.1 mg | EUR 260.7 |
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Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol. |
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Kidney Tissue Lysate (Normal) |
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| 1706-04 | ProSci | 0.1 mg | EUR 260.7 |
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Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol. |
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Kidney Tissue Lysate (Normal) |
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| 1706-05 | ProSci | 0.1 mg | EUR 260.7 |
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Description: Kidney tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol. |
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Normal kidney tissue array |
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| KD803 | TissueArray | each | EUR 354 |
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Description: Normal kidney tissue array, replacing BN07012, 80 cases/80 cores |
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Normal kidney tissue array |
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| KDN242 | TissueArray | each | EUR 72 |
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Description: Normal kidney tissue array, 24 cases/24 cores |
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Normal kidney and normal adjacent kidney tissue array |
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| KDN241a | TissueArray | each | EUR 138 |
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Description: Normal kidney and normal adjacent kidney tissue array, 24 cases/ 24 cores |
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cDNA from Rat Normal Tissue: Adipose |
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| C1434003 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Bladder |
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| C1434010 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Brain |
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| C1434035 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Colon |
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| C1434090 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Heart |
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| C1434122 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Liver |
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| C1434149 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Lung |
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| C1434152 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Placenta |
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| C1434200 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Rectum |
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| C1434206 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Spleen |
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| C1434246 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Stomach |
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| C1434248 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Testis |
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| C1434260 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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Kidney cancer tissue array with normal Kidney tissue |
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| KD2082a | TissueArray | each | EUR 474 |
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Description: Kidney cancer tissue array with normal Kidney tissue, including TNM and pathology grade, 96 cases/192 cores, replacing KD2082 |
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cDNA from Human Tumor Tissue: Kidney |
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| C1235142 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Diabetic Tissue: Kidney |
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| C1236142Dia | Biochain | 40 reactions | EUR 801.6 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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Kidney cancer tissue array with adjacent normal kidney tissue |
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| BC07015b | TissueArray | each | EUR 168 |
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Description: Kidney cancer tissue array with adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 72 cases/72 cores, replacing BC07015a |
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Matching Pair - cDNA from Human Primary Tumor and Normal Tissue: Kidney |
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| C8235142-PP | Biochain | 10 reactions x2 | EUR 598.8 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Skeletal Muscle |
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| C1434171 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Rat Normal Tissue: Small Intestine |
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| C1434226 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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Kidney cancer tissue array with matched adjacent normal kidney tissue |
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| KD901a | TissueArray | each | EUR 258 |
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Description: Kidney cancer tissue array with matched adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 40 cases/90 cores, replacing KD901 |
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cDNA from Mouse Normal Tissue: Adipose |
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| C1334003 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Bladder |
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| C1334010 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Brain |
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| C1334035 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Colon |
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| C1334090 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Heart |
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| C1334122 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Liver |
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| C1334149 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Lung |
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| C1334152 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Placenta |
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| C1334200 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Rectum |
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| C1334206 | Biochain | 40 reactions | EUR 648 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Spleen |
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| C1334246 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Stomach |
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| C1334248 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Testis |
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| C1334260 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Bladder |
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| C1734010 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Brain |
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| C1734035 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Cecum |
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| C1734089 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Esophagus |
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| C1734106 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Heart |
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| C1734122 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Liver |
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| C1734149 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Lung |
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| C1734152 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Trachea |
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| C1734160 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Pancreas |
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| C1734188 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Rectum |
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| C1734206 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Stomach |
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| C1734248 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Dog Normal Tissue: Testis |
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| C1734260 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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Monkey (Cynomolgus) cDNA Normal Tissue: Liver |
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| MC34-149 | Alpha Diagnostics | 10 rxn | EUR 498 |
Monkey (Cynomolgus) cDNA Normal Tissue: Pancreas |
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| MC34-188 | Alpha Diagnostics | 10 rxn | EUR 498 |
Monkey (Cynomolgus) cDNA Normal Tissue: Spleen |
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| MC34-246 | Alpha Diagnostics | 10 rxn | EUR 498 |
Genomic DNA from Rat Normal Tissue: Kidney |
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| D1434142 | Biochain | 100 ug | EUR 338.4 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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Total RNA from Rat Normal Tissue: Kidney |
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| R1434142-50 | Biochain | 50 ug | EUR 182.4 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Plant Normal Tissue: cDNA from Plant: Arabidopsis |
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| C1634310 | Biochain | 40 reactions | EUR 745.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Plant Normal Tissue: cDNA from Plant: Corn |
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| C1634330 | Biochain | 40 reactions | EUR 745.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Plant Normal Tissue: cDNA from Plant: Orange |
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| C1634340 | Biochain | 40 reactions | EUR 745.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Plant Normal Tissue: cDNA from Plant: Potato |
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| C1634350 | Biochain | 40 reactions | EUR 745.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Plant Normal Tissue: cDNA from Plant: Rice |
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| C1634360 | Biochain | 40 reactions | EUR 745.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Plant Normal Tissue: cDNA from Plant: Wheat |
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| C1634390 | Biochain | 40 reactions | EUR 745.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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Rat Kidney Tissue Preparation Buffer 2: Normal Kidney Epithelial Cells |
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| 9-80263 | CHI Scientific | 1 x 100 ml | Ask for price |
Kidney tumour with normal tissue array |
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| KD2001 | TissueArray | each | EUR 474 |
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Description: Kidney tumour with normal tissue array, including Clear cell carcinoma (CCRCC), Sarcomatoid carcinoma, Papillary renal cell carcinoma (PRCC), Chromopobe carcinoma(crcc), Invasive low grade urothelial carcinoma, with Isup Grade, TNM/Stage (AJCC 8th edition), 100 cases/200 cores (core size 1.0mm),replacing BC07114 |
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Adjacent normal kidney tissue and cancer tissue array |
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| BN07011b | TissueArray | each | EUR 203 |
|
Description: Adjacent normal kidney tissue and cancer tissue array, including pathology grade, TNM and clinical stage, 20 cases/54 cores, replacing BN07011 |
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Kidney cancer with matched adjacent normal kidney tissue array |
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| KD603 | TissueArray | each | EUR 204 |
|
Description: Kidney cancer with matched adjacent normal kidney tissue array, containing metastatic clear cell carcinoma, including pathology grade, TNM and clinical stage (reference AJCC 8th version), 33 cases/61 cores |
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cDNA from Plant Normal Tissue: cDNA from Plant: Soy bean |
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| C1634370 | Biochain | 40 reactions | EUR 745.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Adipose |
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| C1234003-10 | Biochain | 10 reactions | EUR 277.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Adrenal |
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| C1234004 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Bladder |
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| C1234010 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Brain |
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| C1234035 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Breast |
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| C1234086 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Colon |
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| C1234090 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Esophagus |
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| C1234106 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Heart |
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| C1234122 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Liver |
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| C1234149 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Lung |
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| C1234152 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Trachea |
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| C1234160-10 | Biochain | 10 reactions | EUR 277.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Ovary |
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| C1234183 | Biochain | 40 reactions | EUR 1126.8 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Pancreas |
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| C1234188 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Placenta |
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| C1234200 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Prostate |
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| C1234201 | Biochain | 40 reactions | EUR 451.2 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Rectum |
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| C1234206 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Skin |
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| C1234218 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Spleen |
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| C1234246 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Stomach |
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| C1234248 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Testis |
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| C1234260 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Theca |
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| C1234261-10 | Biochain | 10 reactions | EUR 277.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Throat |
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| C1234263-10 | Biochain | 10 reactions | EUR 277.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Thymus |
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| C1234264 | Biochain | 40 reactions | EUR 1126.8 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Thyroid |
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| C1234265 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Tongue |
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| C1234267-10 | Biochain | 10 reactions | EUR 277.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Tonsil |
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| C1234268-10 | Biochain | 10 reactions | EUR 277.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Human Adult Normal Tissue: Uterus |
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| C1234274 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Skeletal Muscle |
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| C1334171 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Mouse Normal Tissue: Small Intestine |
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| C1334226 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Adipose |
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| C1534003 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Adipose |
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| C1534003-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Adrenal |
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| C1534004 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Adrenal |
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| C1534004-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Appendix |
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| C1534006 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Appendix |
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| C1534006-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Bladder |
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| C1534010 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Bladder |
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| C1534010-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Brain |
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| C1534035 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Brain |
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| C1534035-Cy | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Brain:Cerebellum |
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| C1534039-Cy | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Cecum |
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| C1534089 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Cecum |
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| C1534089-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Colon |
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| C1534090 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Colon |
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| C1534090-Cy | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Epididymis |
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| C1534105 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Epididymis |
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| C1534105-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Esophagus |
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| C1534106 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Esophagus |
|||
| C1534106-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Gallbladder |
|||
| C1534118 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Gallbladder |
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| C1534118-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Heart |
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| C1534122 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Heart |
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| C1534122-Cy | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Liver |
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| C1534149 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Liver |
|||
| C1534149-Cy | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Lung |
|||
| C1534152 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Lung |
|||
| C1534152-Cy | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Rhesus) Normal Tissue: Trachea |
|||
| C1534160 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Cynomolgus) Normal Tissue: Trachea |
|||
| C1534160-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Rhesus) Normal Tissue: Diaphragm |
|||
| C1534169 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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cDNA from Monkey (Cynomolgus) Normal Tissue: Diaphragm |
|||
| C1534169-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Rhesus) Normal Tissue: Ovary |
|||
| C1534183 | Biochain | 40 reactions | EUR 1126.8 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Cynomolgus) Normal Tissue: Ovary |
|||
| C1534183-Cy | Biochain | 40 reactions | EUR 1126.8 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Rhesus) Normal Tissue: Pancreas |
|||
| C1534188 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Cynomolgus) Normal Tissue: Pancreas |
|||
| C1534188-Cy | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Rhesus) Normal Tissue: Parathyroid |
|||
| C1534189 | Biochain | 40 reactions | EUR 1261.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Cynomolgus) Normal Tissue: Parathyroid |
|||
| C1534189-Cy | Biochain | 40 reactions | EUR 1261.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Rhesus) Normal Tissue: Parotid |
|||
| C1534190 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Cynomolgus) Normal Tissue: Parotid |
|||
| C1534190-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Rhesus) Normal Tissue: Penis |
|||
| C1534194 | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Cynomolgus) Normal Tissue: Penis |
|||
| C1534194-Cy | Biochain | 40 reactions | EUR 648 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Rhesus) Normal Tissue: Placenta |
|||
| C1534200 | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
cDNA from Monkey (Cynomolgus) Normal Tissue: Placenta |
|||
| C1534200-Cy | Biochain | 40 reactions | EUR 451.2 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
|||
Bovendien promootte NOL4L de ontwikkeling en uitzaaiing van tumoren in een naakte muizenpop. Mechanistisch hebben we aangetoond dat NOL4L genexpressie binnen de PI3K/AKT-route beïnvloedde. In totaal levert ons onderzoek genetisch en biochemisch bewijs dat NOL4L belangrijk is voor tumorontwikkeling en metastase in de meeste kankercellen van de eierstokken. Het kan dus een doel zijn voor antimetastatische remedie bij de meeste eierstokkankers.
